Total synthesis of PDIM A

Tatsuya Nakamura, Hanae Nakagome, Shoichiro Sano, Tomoko Sadayuki, Seijiro Hosokawa

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    4 Citations (Scopus)

    Abstract

    Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

    Original languageEnglish
    Pages (from-to)550-551
    Number of pages2
    JournalChemistry Letters
    Volume45
    Issue number5
    DOIs
    Publication statusPublished - 2016

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    Keywords

    • Phthiocerol dimycocerosate A (PDIM A)
    • Total synthesis
    • Tuberculosis

    ASJC Scopus subject areas

    • Chemistry(all)

    Cite this

    Nakamura, T., Nakagome, H., Sano, S., Sadayuki, T., & Hosokawa, S. (2016). Total synthesis of PDIM A. Chemistry Letters, 45(5), 550-551. https://doi.org/10.1246/cl.160152