Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment

Kazuo Nagasawa, Isao Shimizu, Tadashi Nakata

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.

    Original languageEnglish
    Pages (from-to)6881-6884
    Number of pages4
    JournalTetrahedron Letters
    Volume37
    Issue number38
    DOIs
    Publication statusPublished - 1996 Sep 16

    Fingerprint

    Ethylene Oxide
    Hydrogenolysis
    Epoxidation
    allyl alcohol
    polyol

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment. / Nagasawa, Kazuo; Shimizu, Isao; Nakata, Tadashi.

    In: Tetrahedron Letters, Vol. 37, No. 38, 16.09.1996, p. 6881-6884.

    Research output: Contribution to journalArticle

    Nagasawa, Kazuo ; Shimizu, Isao ; Nakata, Tadashi. / Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment. In: Tetrahedron Letters. 1996 ; Vol. 37, No. 38. pp. 6881-6884.
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