Total synthesis of preswinholide A. 1. Stereoselective synthesis of the C11-C23 segment

Kazuo Nagasawa, Isao Shimizu, Tadashi Nakata

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    The C11-C23 segment of preswinholide A was stereoselectively synthesized based on the iterative construction of 1,3-polyol chains using a series of sequential reactions which involves the Sharpless asymmetric epoxidation of allyl alcohol and Pd-catalyzed hydrogenolysis of alkenyl oxirane with HCOOH as the key reactions.

    Original languageEnglish
    Pages (from-to)6881-6884
    Number of pages4
    JournalTetrahedron Letters
    Issue number38
    Publication statusPublished - 1996 Sep 16


    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

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