Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives

Lauren E. Buerkle, Horst A. Von Recum, Stuart J. Rowan

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

We report the synthesis and study of a new guanosine-based hydrogelator, 8-methoxy-2′,3′,5′-tri-O-acetylguanosine, that can not only gel aqueous solutions at biologically relevant salt concentrations, but can also gel cell media. Studies suggest that this hydrogelator forms helical assemblies, rather than the macrocyclic quartet assemblies commonly found in guanosine hydrogels, which allow it to form hydrogels at as low as 0.5 wt% in 100mM NaCl. Furthermore, we show that this gelator is non-toxic to cells, injectable and that by simply mixing with 2′,3′,5′-tri-O- acetylguanosine, we can systematically vary the modulus and shear sensitivity of the gel over orders of magnitude.

Original languageEnglish
Pages (from-to)564-572
Number of pages9
JournalChemical Science
Volume3
Issue number2
DOIs
Publication statusPublished - 2012 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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