Abstract
To test the hypotheses that plasma volume (PV) expansion 24 h after intense exercise is associated with reduced transcapillary escape rate of albumin (TER(alb)) and that local changes in transcapillary forces in the previously active tissues favor retention of protein in the vascular space, we measured PV, TER(alb), plasma colloid osmotic pressure (COP(p)), interstitial fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg muscle and skin and capillary filtration coefficient (CFC) in the arm and leg in seven men and women before and 24 h after intense upright cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to 6.3 ± 0.1 g/dl, P < 0.05) and COP(p) (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma albumin concentration was unchanged. TER(alb) tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV (r = -0.69, P < 0.05). CFC increased in the leg (3.2 ± 0.2 to 4.3 ± 0.5 μl · 100 g-1 · min-1 mmHg-1, P < 0.05), and Pi showed a trend to increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data demonstrate that TER(alb) is associated with PV regulation and that local transcapillary forces in the leg muscle may favor retention of albumin in the vascular space after exercise.
| Original language | English |
|---|---|
| Pages (from-to) | 407-413 |
| Number of pages | 7 |
| Journal | Journal of Applied Physiology |
| Volume | 83 |
| Issue number | 2 |
| Publication status | Published - 1997 Aug |
| Externally published | Yes |
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Keywords
- Capillary filtration coefficient
- Evans blue dye
- Interstitial fluid colloid osmotic pressure
- Interstitial fluid hydrostatic pressure
- Plasma volume
ASJC Scopus subject areas
- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. / Haskell, Andrew; Nadel, Ethan R.; Stachenfeld, Nina S.; Nagashima, Kei; Mack, Gary W.
In: Journal of Applied Physiology, Vol. 83, No. 2, 08.1997, p. 407-413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia
AU - Haskell, Andrew
AU - Nadel, Ethan R.
AU - Stachenfeld, Nina S.
AU - Nagashima, Kei
AU - Mack, Gary W.
PY - 1997/8
Y1 - 1997/8
N2 - To test the hypotheses that plasma volume (PV) expansion 24 h after intense exercise is associated with reduced transcapillary escape rate of albumin (TER(alb)) and that local changes in transcapillary forces in the previously active tissues favor retention of protein in the vascular space, we measured PV, TER(alb), plasma colloid osmotic pressure (COP(p)), interstitial fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg muscle and skin and capillary filtration coefficient (CFC) in the arm and leg in seven men and women before and 24 h after intense upright cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to 6.3 ± 0.1 g/dl, P < 0.05) and COP(p) (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma albumin concentration was unchanged. TER(alb) tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV (r = -0.69, P < 0.05). CFC increased in the leg (3.2 ± 0.2 to 4.3 ± 0.5 μl · 100 g-1 · min-1 mmHg-1, P < 0.05), and Pi showed a trend to increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data demonstrate that TER(alb) is associated with PV regulation and that local transcapillary forces in the leg muscle may favor retention of albumin in the vascular space after exercise.
AB - To test the hypotheses that plasma volume (PV) expansion 24 h after intense exercise is associated with reduced transcapillary escape rate of albumin (TER(alb)) and that local changes in transcapillary forces in the previously active tissues favor retention of protein in the vascular space, we measured PV, TER(alb), plasma colloid osmotic pressure (COP(p)), interstitial fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg muscle and skin and capillary filtration coefficient (CFC) in the arm and leg in seven men and women before and 24 h after intense upright cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to 6.3 ± 0.1 g/dl, P < 0.05) and COP(p) (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma albumin concentration was unchanged. TER(alb) tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV (r = -0.69, P < 0.05). CFC increased in the leg (3.2 ± 0.2 to 4.3 ± 0.5 μl · 100 g-1 · min-1 mmHg-1, P < 0.05), and Pi showed a trend to increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data demonstrate that TER(alb) is associated with PV regulation and that local transcapillary forces in the leg muscle may favor retention of albumin in the vascular space after exercise.
KW - Capillary filtration coefficient
KW - Evans blue dye
KW - Interstitial fluid colloid osmotic pressure
KW - Interstitial fluid hydrostatic pressure
KW - Plasma volume
UR - http://www.scopus.com/inward/record.url?scp=0030860874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030860874&partnerID=8YFLogxK
M3 - Article
C2 - 9262434
AN - SCOPUS:0030860874
VL - 83
SP - 407
EP - 413
JO - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
JF - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
SN - 8750-7587
IS - 2
ER -