Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia

Andrew Haskell, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, Gary W. Mack

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

To test the hypotheses that plasma volume (PV) expansion 24 h after intense exercise is associated with reduced transcapillary escape rate of albumin (TER(alb)) and that local changes in transcapillary forces in the previously active tissues favor retention of protein in the vascular space, we measured PV, TER(alb), plasma colloid osmotic pressure (COP(p)), interstitial fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg muscle and skin and capillary filtration coefficient (CFC) in the arm and leg in seven men and women before and 24 h after intense upright cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to 6.3 ± 0.1 g/dl, P < 0.05) and COP(p) (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma albumin concentration was unchanged. TER(alb) tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV (r = -0.69, P < 0.05). CFC increased in the leg (3.2 ± 0.2 to 4.3 ± 0.5 μl · 100 g-1 · min-1 mmHg-1, P < 0.05), and Pi showed a trend to increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data demonstrate that TER(alb) is associated with PV regulation and that local transcapillary forces in the leg muscle may favor retention of albumin in the vascular space after exercise.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalJournal of Applied Physiology
Volume83
Issue number2
Publication statusPublished - 1997 Aug
Externally publishedYes

Fingerprint

Plasma Volume
Albumins
Leg
Exercise
Osmotic Pressure
Colloids
Serum Albumin
Muscles
Blood Vessels
Hydrostatic Pressure
Extracellular Fluid
Proteins
Arm
Skin

Keywords

  • Capillary filtration coefficient
  • Evans blue dye
  • Interstitial fluid colloid osmotic pressure
  • Interstitial fluid hydrostatic pressure
  • Plasma volume

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Haskell, A., Nadel, E. R., Stachenfeld, N. S., Nagashima, K., & Mack, G. W. (1997). Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. Journal of Applied Physiology, 83(2), 407-413.

Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. / Haskell, Andrew; Nadel, Ethan R.; Stachenfeld, Nina S.; Nagashima, Kei; Mack, Gary W.

In: Journal of Applied Physiology, Vol. 83, No. 2, 08.1997, p. 407-413.

Research output: Contribution to journalArticle

Haskell, A, Nadel, ER, Stachenfeld, NS, Nagashima, K & Mack, GW 1997, 'Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia', Journal of Applied Physiology, vol. 83, no. 2, pp. 407-413.
Haskell, Andrew ; Nadel, Ethan R. ; Stachenfeld, Nina S. ; Nagashima, Kei ; Mack, Gary W. / Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. In: Journal of Applied Physiology. 1997 ; Vol. 83, No. 2. pp. 407-413.
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