Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis

Etsuro Ito, Miki Yamagishi, Yusuke Yamagishi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Conditioned taste aversion (CTA) can be classically conditioned in the pond snail Lymnaea stagnalis and subsequently be consolidated into long-term memory (LTM). The neural mechanism that subserves CTA-LTM are summarized as follows: A polysynaptic inhibitory postsynaptic potential recorded in the neuron 1 medial (N1M) cell in the buccal ganglion of the conditioned snails as a result of activation of the cerebral giant cell (CGC) is larger and lasts longer than that in control snails. The N1M cell is the member of feeding central pattern generator, whereas the CGC is a multimodal interneuron thought to play a key role in the feeding behavior. The CGC is serotonergic and the secretion of setotonin from the CGC is controlled by cAMP, PKA and CREB, showing that these signaling cascades are involved in CTA. In this chapter we review the transcription mechanism, partuculary the cascades of cAMP-PKA-CREB and CCAAT/enhancer binding protein, in CTA-LTM.

Original languageEnglish
Title of host publicationMemory Consolidation
PublisherNova Science Publishers, Inc.
Pages111-126
Number of pages16
ISBN (Electronic)9781634826235
ISBN (Print)9781634825962
Publication statusPublished - 2015 Oct 1
Externally publishedYes

Fingerprint

Lymnaea
Snails
Giant Cells
Long-Term Memory
Neurons
Feeding Behavior
Central Pattern Generators
CCAAT-Enhancer-Binding Proteins
Inhibitory Postsynaptic Potentials
Cheek
Interneurons
Ganglia

Keywords

  • cAMP
  • CCAAT/enhancer binding protein
  • Cerebral giant cell
  • Conditioned taste aversion
  • CREB
  • Lymnaea
  • PKA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ito, E., Yamagishi, M., & Yamagishi, Y. (2015). Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis. In Memory Consolidation (pp. 111-126). Nova Science Publishers, Inc..

Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis. / Ito, Etsuro; Yamagishi, Miki; Yamagishi, Yusuke.

Memory Consolidation. Nova Science Publishers, Inc., 2015. p. 111-126.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ito, E, Yamagishi, M & Yamagishi, Y 2015, Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis. in Memory Consolidation. Nova Science Publishers, Inc., pp. 111-126.
Ito E, Yamagishi M, Yamagishi Y. Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis. In Memory Consolidation. Nova Science Publishers, Inc. 2015. p. 111-126
Ito, Etsuro ; Yamagishi, Miki ; Yamagishi, Yusuke. / Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis. Memory Consolidation. Nova Science Publishers, Inc., 2015. pp. 111-126
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