Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo

Zhen Yan, Ping Li, Takayuki Akimoto

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor γ coactivator 1α gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1α gene in skeletal muscle in vivo.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalExercise and Sport Sciences Reviews
Volume35
Issue number3
DOIs
Publication statusPublished - 2007 Jul 1

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Keywords

  • Exercise
  • Fiber-type switching
  • Mitochondrial biogenesis
  • Peroxisome proliferator-activated receptor γ coactivator 1α
  • Signal transduction
  • Skeletal muscle adaptation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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