Abstract
Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor γ coactivator 1α gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1α gene in skeletal muscle in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 97-101 |
| Number of pages | 5 |
| Journal | Exercise and Sport Sciences Reviews |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Jul |
Keywords
- Exercise
- Fiber-type switching
- Mitochondrial biogenesis
- Peroxisome proliferator-activated receptor γ coactivator 1α
- Signal transduction
- Skeletal muscle adaptation
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation