Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo

Zhen Yan, Ping Li, Takayuki Akimoto

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor γ coactivator 1α gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1α gene in skeletal muscle in vivo.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalExercise and Sport Sciences Reviews
Volume35
Issue number3
DOIs
Publication statusPublished - 2007 Jul

Fingerprint

Skeletal Muscle
Activating Transcription Factor 2
MEF2 Transcription Factors
Peroxisome Proliferator-Activated Receptors
Histone Deacetylases
Organelle Biogenesis
p38 Mitogen-Activated Protein Kinases
Transcriptional Activation
Genes

Keywords

  • Exercise
  • Fiber-type switching
  • Mitochondrial biogenesis
  • Peroxisome proliferator-activated receptor γ coactivator 1α
  • Signal transduction
  • Skeletal muscle adaptation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo. / Yan, Zhen; Li, Ping; Akimoto, Takayuki.

In: Exercise and Sport Sciences Reviews, Vol. 35, No. 3, 07.2007, p. 97-101.

Research output: Contribution to journalReview article

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