Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510

Takuji Nakashima, Ryuki Okuyama, Yoshiyuki Kamiya, Atsuko Matsumoto, Masato Iwatsuki, Yuki Inahashi, Kenzaburo Yamaji, Yoko Takahashi, Satoshi Omura

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Three new natural products, designated trehangelins A, B and C, were isolated by solvent extraction, silica gel and octadecylsilyl silica gel column chromatographies and subsequent preparative HPLC from the cultured broth of an endophytic actinomycete strain, Polymorphospora rubra K07-0510. The trehangelins consisted of a trehalose moiety and two angelic acid moieties. Trehangelins A (IC 50 value, 0.1 mg ml -1) and C (IC 50 value, 0.4 mg ml -1), with symmetric structures, showed potent inhibitory activity against hemolysis of red blood cells induced by light-activated pheophorbide a. However, trehangelin B, with an asymmetric structure, displayed only a slight inhibition (IC 50 value, 1.0 mg ml -1).

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalJournal of Antibiotics
Volume66
Issue number6
DOIs
Publication statusPublished - 2013 Jun
Externally publishedYes

Keywords

  • chemical screening
  • endophytic actinomycete
  • hemolysis inhibitor
  • Polymorphospora rubra
  • trehangelins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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