Trichopolyn VI: A new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system

Takuya Suga, Yukihiro Asami, Shohei Hashimoto, Kenichi Nonaka, Masato Iwatsuki, Takuji Nakashima, Yoshihiro Watanabe, Ryohei Sugahara, Takahiro Shiotsuki, Takenori Yamamoto, Yasuo Shinohara, Naoya Ichimaru, Masatoshi Murai, Hideto Miyoshi, Satoshi Ōmura, Kazuro Shiomi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In the course of searching for insecticides from soil microorganisms, we found that a fermentation broth of the fungus, Trichoderma brevicompactum FKI-6324, produced Trichopolyn VI, a new peptaibol, which possessed significant insecticidal potential. Spectroscopic analysis showed the compound to be a new trichopolyn I derivative. This paper describes the isolation, structure elucidation and biological activity of trichopolyn VI.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalJournal of General and Applied Microbiology
Volume61
Issue number3
DOIs
Publication statusPublished - 2015 Jul 29
Externally publishedYes

Keywords

  • Insecticide
  • Peptaibol
  • Saccharomyces cerevisiae
  • Trichoderma brevicompactum
  • Trichopolyn

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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