Abstract
Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.
Original language | English |
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Pages (from-to) | 582-585 |
Number of pages | 4 |
Journal | Journal of Antibiotics |
Volume | 60 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2007 Sep |
Externally published | Yes |
Keywords
- ER stress
- Triene-ansamycin
- Trierixin
- XBP1
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery