Triple helical collagen-like peptides

Engineering and applications in matrix biology

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Collagen, a large insoluble protein with a characteristic triple helical structure, is found as the most prominent component of extracellular matrix. The functions of collagen are not limited to providing mechanical strength to various tissues and organs as a structural protein, as it has been pointed out that collagen exhibits various biological functions through specific interactions with other macromolecules. However, the use of native triple helical collagen is often troublesome because of its insolubility and gelating properties. Instead, triple helical collagen-like peptides have been designed and are used as collagen surrogates in studies on collagen structure, stability, and biological functions including binding to other proteins and cultured cells. This article reviews recent progress in peptide design, synthesis, and the applications of collagen-like peptides in current matrix biology, while emphasizing the advantages of the peptide-based strategy.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalConnective Tissue Research
Volume46
Issue number3
DOIs
Publication statusPublished - 2005
Externally publishedYes

Fingerprint

Collagen
Peptides
Proteins
Macromolecules
Strength of materials
Extracellular Matrix
Cultured Cells
Solubility
Cells
Tissue

Keywords

  • Collagen
  • Peptides
  • Triple helix

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Nephrology
  • Cell Biology
  • Orthopedics and Sports Medicine

Cite this

Triple helical collagen-like peptides : Engineering and applications in matrix biology. / Koide, Takaki.

In: Connective Tissue Research, Vol. 46, No. 3, 2005, p. 131-141.

Research output: Contribution to journalArticle

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