tRNA recognition by CCA-adding enzyme.

Yukihide Tomari, Tsutomu Suzuki, Takuya Ueda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The CCA-adding enzyme [ATP (CTP): tRNA nucleotidyltransferase (EC. 2.7.7.25)] catalyzes the addition of the conserved CCA sequence to the 3'-terminus of tRNAs. It is known that CCA-adding enzymes from all three kingdoms recognize the elbow region of L-shape tRNA formed by the tertiary interaction between T-loop and D-loop. We here demonstrate that C. elegans mitochondrial CCA-adding enzyme has broad substrate specificity toward nematode mitochondrial tRNAs which lack entire T- or D-arms, by cloning and characterizing the recombinant protein.

Original languageEnglish
Pages (from-to)77-78
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Medicine(all)

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