Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock

Kazumasa Horikawa, Kazuyuki Fuji, Yuka Fukazawa, Shigenobu Shibata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalJournal of Pharmacological Sciences
Volume123
Issue number4
DOIs
Publication statusPublished - 2013 Dec 1

Keywords

  • Circadian clock
  • Non-photic
  • Serotonin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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