Two types of totally artificial red blood cell substitutes liposome embedded heme(L/H) and lipidheme/microsphere(LHM)

K. Kobayashi, T. Kakizaki, T. Komatsu, Hiroyuki Nishide, E. Tsuchida

Research output: Contribution to journalArticle

Abstract

Two types of totally artificial oxygen carriers were produced (1) by embedding synthetic lipidhemes (as oxygen carriers) in bilayers of liposomes as vehicles of lipidhemes(L/H) and (2) by covering clinically available fat droplets (triglyceride microspheres) with synthetic lipidhemes(LHM). Fat droplets were used as vehicles of lipidhemes. Their oxygen carrying ability in vivo was examined in beagles undergoing hemorrhagic shock. L/H delivered 15.7 to 19.2% of total oxygen delivery. From 12.7 to 24.4% of total oxygen consumption was from L/H. LHM delivered 11.6 to 7.3% of total oxygen delivery. From 13.1 to 16.4% of total oxygen consumption was from LHM. These totally synthetic red blood cell substitutes can be candidates for future clinical testing.

Original languageEnglish
Pages (from-to)895-900
Number of pages6
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number3
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

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