Two types of totally synthetic oxygen carrier: Liposome embedded heme(L/H) and lipid heme microshere(LH-M)

Two types of totally artificial oxygen carrying substances are produced. In both systems, synthetic hemes are used as oxygen carrier. In liposome embedded heme system (L/H), synthetic hemes are embedded in bilayers of liposome as vehicles of hemes. In lipid heme microsphere system (LH-M), synthetic hemes are arranged to cover the surface of fat microspheres as vehicles of hemes. Design, physicochemical characteristics, solution properties, oxygen binding capacity in vitro of both materials were discussed. In vivo oxygen carrying ability of the L/H and LH-M was studied in dogs undergoing hemorrhagic shock by drawing 30 ml/kg of blood.