Ultrasensitive detection of biomolecules using functionalized multi-walled carbon nanotubes

Ping An Hu, Takashi Tanii, Guo Jun Zhang, Takumi Hosaka, Iwao Ohdomari

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

An ultrasensitive and facile bioassay approach is developed using biofunctional multi-walled carbon nanotubes (MWNTs). The biofunctional MWNTs are exploited to detect trace protein in the homogeneous solution using fluorescent detection. The effect of target concentration on the fluorescent intensity is systematically studied, revealing that the detected signal is strengthened with increase in target concentration. The homogenous target-capture process performed on the biofunctional MWNTs enhances the detection sensitivity largely. The detection limit of 100 pg/ml is achieved through this bioassay.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume124
Issue number1
DOIs
Publication statusPublished - 2007 Jun 10

Keywords

  • Biomolecules
  • Carbon nanotubes
  • Detection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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