Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains

J. Mizutani, Takuya Chiba, M. Tanaka, K. Higuchi, Masayuki Mori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mitochondrial DNA (mtDNA) is exclusively inherited maternally and hence could offer a good method for tracing the lineage of mouse strains. We examined the mtDNA sequence of senescence-accelerated mouse (SAM) strains as well as other laboratory strains of inbred mice to deduce the ancestral strain of SAM. Four unique mutations were identified at bases 2256, 10,847, 11,181, and 13,053 in SAM strains. The mutations were not found in other mouse strains including AKR/J, one of the parental strains of SAM. Comparison of the mtDNA sequences also led to the consensus mtDNA sequence of laboratory strains of inbred mice. The seven laboratory strains of common inbred mice showed polymorphisms at base 9348, thymine repeat from base 9818, and adenine repeat from base 9821, and could be classified into five types by combination of the differences. Although we could not identify mouse strains with the same type of mtDNA as SAM in this study, the polymorphisms would provide a promising clue to ascertain the ancestral strain(s) of SAM. The polymorphism in mtDNA could be used to ascertain the genealogy of other mouse strains as well.

Original languageEnglish
Pages (from-to)352-355
Number of pages4
JournalJournal of Heredity
Volume92
Issue number4
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Mitochondrial DNA
mitochondrial DNA
mutation
Mutation
mice
Inbred Strains Mice
genetic polymorphism
nucleotide sequences
Genealogy and Heraldry
Thymine
Adenine
thymine
adenine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Mizutani, J., Chiba, T., Tanaka, M., Higuchi, K., & Mori, M. (2001). Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains. Journal of Heredity, 92(4), 352-355.

Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains. / Mizutani, J.; Chiba, Takuya; Tanaka, M.; Higuchi, K.; Mori, Masayuki.

In: Journal of Heredity, Vol. 92, No. 4, 2001, p. 352-355.

Research output: Contribution to journalArticle

Mizutani, J, Chiba, T, Tanaka, M, Higuchi, K & Mori, M 2001, 'Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains', Journal of Heredity, vol. 92, no. 4, pp. 352-355.
Mizutani, J. ; Chiba, Takuya ; Tanaka, M. ; Higuchi, K. ; Mori, Masayuki. / Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains. In: Journal of Heredity. 2001 ; Vol. 92, No. 4. pp. 352-355.
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