Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Ryoko Kibe, Shin Kurihara, Yumi Sakai, Hideyuki Suzuki, Takushi Ooga, Emiko Sawaki, Koji Muramatsu, Atsuo Nakamura, Ayano Yamashita, Yusuke Kitada, Masaki Kakeyama, Yoshimi Benno, Mitsuharu Matsumoto

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.

Original languageEnglish
Article number4548
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - 2014 Apr 1
Externally publishedYes

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Polyamines
Up-Regulation
Arginine
Diptera
Quality of Life
Bifidobacterium
Putrescine
Spermidine
Spermine
Probiotics
Brain
Brain Diseases
Geriatrics
Colon
Yeasts
Inflammation
Bacteria
Food
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • General

Cite this

Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., ... Matsumoto, M. (2014). Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Scientific Reports, 4, [4548]. https://doi.org/10.1038/srep04548

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. / Kibe, Ryoko; Kurihara, Shin; Sakai, Yumi; Suzuki, Hideyuki; Ooga, Takushi; Sawaki, Emiko; Muramatsu, Koji; Nakamura, Atsuo; Yamashita, Ayano; Kitada, Yusuke; Kakeyama, Masaki; Benno, Yoshimi; Matsumoto, Mitsuharu.

In: Scientific Reports, Vol. 4, 4548, 01.04.2014.

Research output: Contribution to journalArticle

Kibe, R, Kurihara, S, Sakai, Y, Suzuki, H, Ooga, T, Sawaki, E, Muramatsu, K, Nakamura, A, Yamashita, A, Kitada, Y, Kakeyama, M, Benno, Y & Matsumoto, M 2014, 'Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice', Scientific Reports, vol. 4, 4548. https://doi.org/10.1038/srep04548
Kibe, Ryoko ; Kurihara, Shin ; Sakai, Yumi ; Suzuki, Hideyuki ; Ooga, Takushi ; Sawaki, Emiko ; Muramatsu, Koji ; Nakamura, Atsuo ; Yamashita, Ayano ; Kitada, Yusuke ; Kakeyama, Masaki ; Benno, Yoshimi ; Matsumoto, Mitsuharu. / Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. In: Scientific Reports. 2014 ; Vol. 4.
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