Abstract
Electric pulses in the range of 1 to 5 kV/cm and of durations 1 to 200 microseconds have been used to open up pores of limited size in various cell types. In the case of erythrocytes, these pores were shown to admit molecules as large as tetrasaccharides. Loading of clinically active drugs has also been attempted. Erythrocytes loaded with drugs can be resealed without loss of the hemoglobin content. With mouse erythrocytes, we have demonstrated the feasibility of using erythrocytes (not hemoglobin depleted ghosts) as drug carriers for prolonging the drug level in the circulation. Other possible applications of the method are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 108-114 |
| Number of pages | 7 |
| Journal | Bibliotheca Haematologica |
| Issue number | 51 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Medicine(all)
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Use of voltage pulses for the pore opening and drug loading, and the subsequent resealing of red blood cells. / Tsong, T. Y.; Kinosita, K.
In: Bibliotheca Haematologica, No. 51, 1985, p. 108-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of voltage pulses for the pore opening and drug loading, and the subsequent resealing of red blood cells.
AU - Tsong, T. Y.
AU - Kinosita, K.
PY - 1985
Y1 - 1985
N2 - Electric pulses in the range of 1 to 5 kV/cm and of durations 1 to 200 microseconds have been used to open up pores of limited size in various cell types. In the case of erythrocytes, these pores were shown to admit molecules as large as tetrasaccharides. Loading of clinically active drugs has also been attempted. Erythrocytes loaded with drugs can be resealed without loss of the hemoglobin content. With mouse erythrocytes, we have demonstrated the feasibility of using erythrocytes (not hemoglobin depleted ghosts) as drug carriers for prolonging the drug level in the circulation. Other possible applications of the method are also discussed.
AB - Electric pulses in the range of 1 to 5 kV/cm and of durations 1 to 200 microseconds have been used to open up pores of limited size in various cell types. In the case of erythrocytes, these pores were shown to admit molecules as large as tetrasaccharides. Loading of clinically active drugs has also been attempted. Erythrocytes loaded with drugs can be resealed without loss of the hemoglobin content. With mouse erythrocytes, we have demonstrated the feasibility of using erythrocytes (not hemoglobin depleted ghosts) as drug carriers for prolonging the drug level in the circulation. Other possible applications of the method are also discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021981097&partnerID=8YFLogxK
M3 - Article
C2 - 4004753
AN - SCOPUS:0021981097
SP - 108
EP - 114
JO - Bibliotheca Haematologica
JF - Bibliotheca Haematologica
SN - 0067-7957
IS - 51
ER -