Usefulness of intraoperative magnetic resonance imaging for glioma surgery.

Y. Muragaki, Hiroshi Iseki, T. Maruyama, T. Kawamata, F. Yamane, R. Nakamura, O. Kubo, K. Takakura, T. Hori

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Radical resection of gliomas can increase patient's survival. There is known concern, however, that aggressive tumour removal can result in neurological morbidity. The objective of the present study was to evaluate the usefulness of low magnetic field strength (0.3 Tesla) open intraoperative magnetic resonance imaging (iMRI) for complete resection of glioma with emphasis on functional outcome. METHODS: From 2000 to 2004, 96 patients with intracranial gliomas underwent tumour resection with the use of iMRI in Tokyo Women's Medical University. There were 50 men and 46 women; mean age was 39 years. Tumour volume varied from 1.2 ml to 198 ml (median: 36.5 mL). Resection rate and postoperative neurological status were compared between control group (46 cases, operated on during the initial period after installation of iMRI), and study group (50 most recent cases, in whom surgery was done using established treatment algorithm and improved image quality). FINDINGS: Overall, mean resection rate was 93%, and medial residual tumour volume was 0.17 ml. Total tumour removal was achieved in 44 cases (46%). Compared to control group, resection rate in the study group was significantly higher (91%, vs. 95%; P < 0.05), whereas residual tumour volume was significantly smaller (1.7 mL vs. 0.025 mL; P < 0.001). Nine patients in the control group (20%) and 24 in the study group (48%) experienced temporary postoperative neurological deterioration (P < 0.01), however, the rate of permanent morbidity evaluated 3 months after surgery did not differ significantly between the groups investigated (13% vs. 14%). CONCLUSIONS: Use of iMRI during surgery for intracranial gliomas permits to attain aggressive tumour resection with good functional outcome. Nevertheless, surgical experience with the iMRI system, establishment of treatment algorithm, and improvement of image quality are of paramount importance for optimal results.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalActa neurochirurgica. Supplement
Volume98
Publication statusPublished - 2006
Externally publishedYes

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Glioma
Magnetic Resonance Imaging
Tumor Burden
Residual Volume
Residual Neoplasm
Control Groups
Neoplasms
Morbidity
Tokyo
Magnetic Fields
Quality Improvement
Survival
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Muragaki, Y., Iseki, H., Maruyama, T., Kawamata, T., Yamane, F., Nakamura, R., ... Hori, T. (2006). Usefulness of intraoperative magnetic resonance imaging for glioma surgery. Acta neurochirurgica. Supplement, 98, 67-75.

Usefulness of intraoperative magnetic resonance imaging for glioma surgery. / Muragaki, Y.; Iseki, Hiroshi; Maruyama, T.; Kawamata, T.; Yamane, F.; Nakamura, R.; Kubo, O.; Takakura, K.; Hori, T.

In: Acta neurochirurgica. Supplement, Vol. 98, 2006, p. 67-75.

Research output: Contribution to journalArticle

Muragaki, Y, Iseki, H, Maruyama, T, Kawamata, T, Yamane, F, Nakamura, R, Kubo, O, Takakura, K & Hori, T 2006, 'Usefulness of intraoperative magnetic resonance imaging for glioma surgery.', Acta neurochirurgica. Supplement, vol. 98, pp. 67-75.
Muragaki Y, Iseki H, Maruyama T, Kawamata T, Yamane F, Nakamura R et al. Usefulness of intraoperative magnetic resonance imaging for glioma surgery. Acta neurochirurgica. Supplement. 2006;98:67-75.
Muragaki, Y. ; Iseki, Hiroshi ; Maruyama, T. ; Kawamata, T. ; Yamane, F. ; Nakamura, R. ; Kubo, O. ; Takakura, K. ; Hori, T. / Usefulness of intraoperative magnetic resonance imaging for glioma surgery. In: Acta neurochirurgica. Supplement. 2006 ; Vol. 98. pp. 67-75.
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abstract = "BACKGROUND: Radical resection of gliomas can increase patient's survival. There is known concern, however, that aggressive tumour removal can result in neurological morbidity. The objective of the present study was to evaluate the usefulness of low magnetic field strength (0.3 Tesla) open intraoperative magnetic resonance imaging (iMRI) for complete resection of glioma with emphasis on functional outcome. METHODS: From 2000 to 2004, 96 patients with intracranial gliomas underwent tumour resection with the use of iMRI in Tokyo Women's Medical University. There were 50 men and 46 women; mean age was 39 years. Tumour volume varied from 1.2 ml to 198 ml (median: 36.5 mL). Resection rate and postoperative neurological status were compared between control group (46 cases, operated on during the initial period after installation of iMRI), and study group (50 most recent cases, in whom surgery was done using established treatment algorithm and improved image quality). FINDINGS: Overall, mean resection rate was 93{\%}, and medial residual tumour volume was 0.17 ml. Total tumour removal was achieved in 44 cases (46{\%}). Compared to control group, resection rate in the study group was significantly higher (91{\%}, vs. 95{\%}; P < 0.05), whereas residual tumour volume was significantly smaller (1.7 mL vs. 0.025 mL; P < 0.001). Nine patients in the control group (20{\%}) and 24 in the study group (48{\%}) experienced temporary postoperative neurological deterioration (P < 0.01), however, the rate of permanent morbidity evaluated 3 months after surgery did not differ significantly between the groups investigated (13{\%} vs. 14{\%}). CONCLUSIONS: Use of iMRI during surgery for intracranial gliomas permits to attain aggressive tumour resection with good functional outcome. Nevertheless, surgical experience with the iMRI system, establishment of treatment algorithm, and improvement of image quality are of paramount importance for optimal results.",
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AU - Yamane, F.

AU - Nakamura, R.

AU - Kubo, O.

AU - Takakura, K.

AU - Hori, T.

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N2 - BACKGROUND: Radical resection of gliomas can increase patient's survival. There is known concern, however, that aggressive tumour removal can result in neurological morbidity. The objective of the present study was to evaluate the usefulness of low magnetic field strength (0.3 Tesla) open intraoperative magnetic resonance imaging (iMRI) for complete resection of glioma with emphasis on functional outcome. METHODS: From 2000 to 2004, 96 patients with intracranial gliomas underwent tumour resection with the use of iMRI in Tokyo Women's Medical University. There were 50 men and 46 women; mean age was 39 years. Tumour volume varied from 1.2 ml to 198 ml (median: 36.5 mL). Resection rate and postoperative neurological status were compared between control group (46 cases, operated on during the initial period after installation of iMRI), and study group (50 most recent cases, in whom surgery was done using established treatment algorithm and improved image quality). FINDINGS: Overall, mean resection rate was 93%, and medial residual tumour volume was 0.17 ml. Total tumour removal was achieved in 44 cases (46%). Compared to control group, resection rate in the study group was significantly higher (91%, vs. 95%; P < 0.05), whereas residual tumour volume was significantly smaller (1.7 mL vs. 0.025 mL; P < 0.001). Nine patients in the control group (20%) and 24 in the study group (48%) experienced temporary postoperative neurological deterioration (P < 0.01), however, the rate of permanent morbidity evaluated 3 months after surgery did not differ significantly between the groups investigated (13% vs. 14%). CONCLUSIONS: Use of iMRI during surgery for intracranial gliomas permits to attain aggressive tumour resection with good functional outcome. Nevertheless, surgical experience with the iMRI system, establishment of treatment algorithm, and improvement of image quality are of paramount importance for optimal results.

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