Using micro and nanofluidics with surface enhanced Raman spectroscopy for in vitro blood based biomarker detection

Gerard L. Coté, Jun Kameoka, Haley Marks

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this presentation we will discuss the development of a point-of-care optofluidic device that uses gold nanoparticlebased surface enhanced Raman spectroscopy (SERS) for detection of blood biomarkers. SERS approaches have been successfully used for detection of analytes due to the large enhancements provided by the interaction between the light, gold particles, and analyte. However, SERS approaches developed for use to accurately quantify an analyte have suffered from a lack of repeatability. We will describe our SERS optofluidic device with functionalized nanoparticles that helps to overcome these problems and will show results with a focus on blood cardiac biomarkers.

Original languageEnglish
Title of host publicationTranslational Biophotonics
PublisherSPIE
ISBN (Print)9780819496263
DOIs
Publication statusPublished - 2014
Externally publishedYes
EventTranslational Biophotonics - Houston, TX, United States
Duration: 2014 May 192014 May 20

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9155
ISSN (Print)1605-7422

Conference

ConferenceTranslational Biophotonics
Country/TerritoryUnited States
CityHouston, TX
Period14/5/1914/5/20

Keywords

  • blood biomarkers
  • nanoparticles
  • optofluidic
  • Point-of-care
  • surface enhanced Raman spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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