Utilization of myosin and actin bundles for the transport of molecular cargo

Hideyo Takatsuki, Kevin M. Rice, Shinichi Asano, B. Scott Day, Mizuki Hino, Kazuhiro Oiwa, Ryoki Ishikawa, Yuichi Hiratsuka, Taro Q.P. Uyeda, Kazuhiro Kohama, Eric R. Blough

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.

Original languageEnglish
Pages (from-to)452-457
Number of pages6
JournalSmall
Volume6
Issue number3
DOIs
Publication statusPublished - 2010 Feb 5
Externally publishedYes

Keywords

  • Actin bundles
  • Cargo transport
  • Fascin
  • Microchannels
  • Myosin

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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