Variability of beta-amyloid protein deposited lesions in Down's syndrome brains.

S. Ikeda, T. Tokuda, N. Yanagisawa, F. Kametani, Toshio Ohshima, D. Allsop

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalTohoku Journal of Experimental Medicine
Volume174
Issue number3
Publication statusPublished - 1994 Nov
Externally publishedYes

Fingerprint

Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Down Syndrome
Brain
Proteins
Amyloid Plaques
tau Proteins
Amyloid
Deposits
Antibodies
Neocortex
Amyloidosis
Alzheimer Disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ikeda, S., Tokuda, T., Yanagisawa, N., Kametani, F., Ohshima, T., & Allsop, D. (1994). Variability of beta-amyloid protein deposited lesions in Down's syndrome brains. Tohoku Journal of Experimental Medicine, 174(3), 189-198.

Variability of beta-amyloid protein deposited lesions in Down's syndrome brains. / Ikeda, S.; Tokuda, T.; Yanagisawa, N.; Kametani, F.; Ohshima, Toshio; Allsop, D.

In: Tohoku Journal of Experimental Medicine, Vol. 174, No. 3, 11.1994, p. 189-198.

Research output: Contribution to journalArticle

Ikeda, S, Tokuda, T, Yanagisawa, N, Kametani, F, Ohshima, T & Allsop, D 1994, 'Variability of beta-amyloid protein deposited lesions in Down's syndrome brains.', Tohoku Journal of Experimental Medicine, vol. 174, no. 3, pp. 189-198.
Ikeda, S. ; Tokuda, T. ; Yanagisawa, N. ; Kametani, F. ; Ohshima, Toshio ; Allsop, D. / Variability of beta-amyloid protein deposited lesions in Down's syndrome brains. In: Tohoku Journal of Experimental Medicine. 1994 ; Vol. 174, No. 3. pp. 189-198.
@article{e8dabaf185534158ad4629324115a0a8,
title = "Variability of beta-amyloid protein deposited lesions in Down's syndrome brains.",
abstract = "An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of {"}early plaque{"} precede the development of tau-immunoreactive neurofibrillary degeneration.",
author = "S. Ikeda and T. Tokuda and N. Yanagisawa and F. Kametani and Toshio Ohshima and D. Allsop",
year = "1994",
month = "11",
language = "English",
volume = "174",
pages = "189--198",
journal = "Tohoku Journal of Experimental Medicine",
issn = "0040-8727",
publisher = "Tohoku University Medical Press",
number = "3",

}

TY - JOUR

T1 - Variability of beta-amyloid protein deposited lesions in Down's syndrome brains.

AU - Ikeda, S.

AU - Tokuda, T.

AU - Yanagisawa, N.

AU - Kametani, F.

AU - Ohshima, Toshio

AU - Allsop, D.

PY - 1994/11

Y1 - 1994/11

N2 - An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.

AB - An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.

UR - http://www.scopus.com/inward/record.url?scp=0028542111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028542111&partnerID=8YFLogxK

M3 - Article

VL - 174

SP - 189

EP - 198

JO - Tohoku Journal of Experimental Medicine

JF - Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 3

ER -