Variations in carotid arterial compliance during the menstrual cycle in young women

Koichiro Hayashi*, Motohiko Miyachi, Natsuki Seno, Kouki Takahashi, Ken Yamazaki, Jun Sugawara, Takashi Yokoi, Sho Onodera, Noboru Mesaki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

The effect of menstrual cycle phase on arterial elasticity is controversial. In 10 healthy women (20.6 ± 1.5 years old, mean ±s.d.), we investigated the variations in central and peripheral arterial elasticity, blood pressure (carotid and brachial), carotid intima-media thickness (IMT), and serum oestradiol and progesterone concentrations at five points in the menstrual cycle (menstrual, M; follicular, F; ovulatory, O; early luteal, EL; and late luteal, LL). Carotid arterial compliance (simultaneous ultrasound and applanation tonometry) varied cyclically, with significant increases from the values seen in M (0.164 ± 0.036 mm2 mmHg-1) and F (0.171 ± 0.029 mm2 mmHg-1) to that seen in the O phase (0.184 ± 0.029 mm2 mmHg -1). Sharp declines were observed in the EL (0.150 ± 0.033 mm2 mmHg-1) and LL phases (0.147 ± 0.026 mm 2 mmHg-1; F = 8.51, P < 0.05). Pulse wave velocity in the leg (i.e. peripheral arterial stiffness) did not exhibit any significant changes. Fluctuations in carotid arterial elasticity correlated with the balance between oestradiol and progesterone concentrations. No significant changes were found in carotid and brachial blood pressures, carotid artery lumen diameter, or IMT throughout the menstrual cycle. These data provide evidence that the elastic properties of central, but not peripheral, arteries fluctuate significantly with the phases of the menstrual cycle.

Original languageEnglish
Pages (from-to)465-472
Number of pages8
JournalExperimental Physiology
Volume91
Issue number2
DOIs
Publication statusPublished - 2006 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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