Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications

Donald C. Aduba, Evan D. Margaretta, Alexandra E.C. Marnot, Katherine V. Heifferon, Wyatt R. Surbey, Nicholas A. Chartrain, Abby R. Whittington, Timothy Edward Long, Christopher B. Williams

    Research output: Contribution to journalArticle

    Abstract

    Additive manufacturing (AM) is an emerging processing platform in clinical applications because of its ability to fabricate customized 3D structures for patient-specific needs. Vat photopolymerization additive manufacturing creates high-resolution, complex structures with excellent accuracy to fulfill these demands. However, materials selection for vat photopolymerization is limited. Many materials lack the biocompatibility and stimuli-responsive properties for biomaterial function in physiological environments. In this work, a vat photopolymerization AM process photocured acid-labile crosslinker within a methacrylate terminated poly(ethylene glycol) polymer network to yield biocompatible 3D structures with diverse architectures. At physiological temperature (37 °C), photocrosslinked networks exhibited thermal stability and tunable water sorption with respect to crosslinker amount. Crosslinker amount and geometry were varied to control dissolution in aqueous physiological environments. Acid-cleavable crosslinker amount increased dissolution in acidic (pH ˜1) environments. In neutral (pH ˜7) environments, acid-cleavable crosslinker amount did not increase dissolution to the same extent. Geometry, specifically cube and lattice structures exhibited differences in dissolution due to surface area driven diffusion. Structural by-products after dissolution demonstrated good in vitro cytocompatibility after 72-hours in culture. This class of 3D-printed biomaterials offer potential for drug delivery, tissue engineering scaffolds and wound dressing applications.

    Original languageEnglish
    Pages (from-to)204-211
    Number of pages8
    JournalMaterials Today Communications
    Volume19
    DOIs
    Publication statusPublished - 2019 Jun 1

    Fingerprint

    Methacrylates
    Photopolymerization
    Biocompatible Materials
    Biomaterials
    3D printers
    Polyethylene glycols
    Printing
    Dissolution
    Acids
    Tissue Scaffolds
    Geometry
    Bioelectric potentials
    Scaffolds (biology)
    Drug delivery
    Biocompatibility
    Tissue engineering
    Byproducts
    Sorption
    Polymers
    Thermodynamic stability

    Keywords

    • 3D printing
    • Acid-cleavable polymers
    • Biocompatibility
    • Personalized medicine
    • Stereolithography

    ASJC Scopus subject areas

    • Materials Science(all)
    • Mechanics of Materials
    • Materials Chemistry

    Cite this

    Aduba, D. C., Margaretta, E. D., Marnot, A. E. C., Heifferon, K. V., Surbey, W. R., Chartrain, N. A., ... Williams, C. B. (2019). Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications. Materials Today Communications, 19, 204-211. https://doi.org/10.1016/j.mtcomm.2019.01.003

    Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications. / Aduba, Donald C.; Margaretta, Evan D.; Marnot, Alexandra E.C.; Heifferon, Katherine V.; Surbey, Wyatt R.; Chartrain, Nicholas A.; Whittington, Abby R.; Long, Timothy Edward; Williams, Christopher B.

    In: Materials Today Communications, Vol. 19, 01.06.2019, p. 204-211.

    Research output: Contribution to journalArticle

    Aduba, DC, Margaretta, ED, Marnot, AEC, Heifferon, KV, Surbey, WR, Chartrain, NA, Whittington, AR, Long, TE & Williams, CB 2019, 'Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications', Materials Today Communications, vol. 19, pp. 204-211. https://doi.org/10.1016/j.mtcomm.2019.01.003
    Aduba, Donald C. ; Margaretta, Evan D. ; Marnot, Alexandra E.C. ; Heifferon, Katherine V. ; Surbey, Wyatt R. ; Chartrain, Nicholas A. ; Whittington, Abby R. ; Long, Timothy Edward ; Williams, Christopher B. / Vat photopolymerization 3D printing of acid-cleavable PEG-methacrylate networks for biomaterial applications. In: Materials Today Communications. 2019 ; Vol. 19. pp. 204-211.
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