Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: Functional MRI study

Shinichiro Takiguchi, Takashi X. Fujisawa, Sakae Mizushima, Daisuke N. Saito, Yuko Okamoto, Koji Shimada, Michiko Koizumi, Hirokazu Kumazaki, Minyoung Jung, Hirotaka Kosaka, Michio Hiratani, Yusei Ohshima, Martin H. Teicher, Akemi Tomoda

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD). Aims To examine whether neural activity during reward processing was altered in children and adolescents with RAD. Method Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging. Results Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups. Conclusions Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalBJPsych Open
Volume1
Issue number2
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: Functional MRI study'. Together they form a unique fingerprint.

  • Cite this

    Takiguchi, S., Fujisawa, T. X., Mizushima, S., Saito, D. N., Okamoto, Y., Shimada, K., Koizumi, M., Kumazaki, H., Jung, M., Kosaka, H., Hiratani, M., Ohshima, Y., Teicher, M. H., & Tomoda, A. (2015). Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: Functional MRI study. BJPsych Open, 1(2), 121-128. https://doi.org/10.1192/bjpo.bp.115.001586