Visceral fat is a strong predictor of insulin resistance regardless of cardiorespiratory fitness in non-diabetic people

Chiyoko Usui, Meiko Asaka, Hiroshi Kawano, Tomoko Aoyama, Toshimichi Ishijima, Shizuo Sakamoto, Mitsuru Higuchi

Research output: Contribution to journalArticle

35 Citations (Scopus)


Abdominal adiposity and low cardiorespiratory fitness are assosicated with insulin resistance in people with impaired glucose tolerance and type 2 diabetes. However, little is known about which factor precedes insulin resistance in people with impaired glucose tolerance and type 2 diabetes, and which is the stronger predictor of insulin resistance in non-diabetic people. The purpose of this study was to examine the relationship between insulin resistance and cardiorespiratory fitness, visceral fat, and subcutaneous fat in non-diabetic people. Subjects included 87 men and 77 women aged 30-72 y (mean±SD, 51.3±12.3 y). Cardiorespiratory fitness was assessed by measuring the maximal oxygen uptake (VO2max) in a progressive continuous test to exhaustion on a cycle ergometer. The visceral and subcutaneous fat areas were measured by magnetic resonance imaging. The homeostasis model assessment of insulin resistance (HOMA-R) was calculated from the fasting concentrations of glucose and insulin. Stepwise multiple linear regression analysis revealed that visceral and subcutaneous fat were significant correlates of HOMA-R, explaining 24% and 6% of the variance, respectively, whereas sex, age, and VO2max were not significant independent determinants. Abdominal fat deposition rather than cardiorespiratory fitness is a significant predictor of insulin resistance in non-diabetic people; visceral fat is the most important factor.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalJournal of Nutritional Science and Vitaminology
Issue number2
Publication statusPublished - 2010



  • Cardiorespiratory fitness
  • Insulin resistance
  • Non-diabetic people
  • Subcutaneous fat
  • Visceral fat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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