Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; An fMRI study

Rayna Azuma, Eileen M. Daly, Linda E. Campbell, Angela F. Stevens, Quinton Deeley, Vincent Giampietro, Michael J. Brammer, Beate Glaser, Fiona Z. Ambery, Robin G. Morris, Steven C R Williams, Michael J. Owen, Declan G M Murphy, Kieran C. Murphy

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)46-60
Number of pages15
JournalJournal of Neurodevelopmental Disorders
Volume1
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

DiGeorge Syndrome
Short-Term Memory
Magnetic Resonance Imaging
Parietal Lobe
Prefrontal Cortex
Brain
Occipital Lobe
Inborn Genetic Diseases
Attention Deficit Disorder with Hyperactivity
Schizophrenia
Chromosomes

Keywords

  • Ageing
  • Schizophrenia
  • Spatial working memory. fMRI
  • Velo-cardio-facial syndrome. 22q11.2 deletion syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cognitive Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; An fMRI study. / Azuma, Rayna; Daly, Eileen M.; Campbell, Linda E.; Stevens, Angela F.; Deeley, Quinton; Giampietro, Vincent; Brammer, Michael J.; Glaser, Beate; Ambery, Fiona Z.; Morris, Robin G.; Williams, Steven C R; Owen, Michael J.; Murphy, Declan G M; Murphy, Kieran C.

In: Journal of Neurodevelopmental Disorders, Vol. 1, No. 1, 2009, p. 46-60.

Research output: Contribution to journalArticle

Azuma, R, Daly, EM, Campbell, LE, Stevens, AF, Deeley, Q, Giampietro, V, Brammer, MJ, Glaser, B, Ambery, FZ, Morris, RG, Williams, SCR, Owen, MJ, Murphy, DGM & Murphy, KC 2009, 'Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; An fMRI study', Journal of Neurodevelopmental Disorders, vol. 1, no. 1, pp. 46-60. https://doi.org/10.1007/s11689-009-9008-9
Azuma, Rayna ; Daly, Eileen M. ; Campbell, Linda E. ; Stevens, Angela F. ; Deeley, Quinton ; Giampietro, Vincent ; Brammer, Michael J. ; Glaser, Beate ; Ambery, Fiona Z. ; Morris, Robin G. ; Williams, Steven C R ; Owen, Michael J. ; Murphy, Declan G M ; Murphy, Kieran C. / Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; An fMRI study. In: Journal of Neurodevelopmental Disorders. 2009 ; Vol. 1, No. 1. pp. 46-60.
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