Vitamin C supplementation does not alter high-intensity endurance training-induced mitochondrial biogenesis in rat epitrochlearis muscle

Koichi Yada, Hideki Matoba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The purpose of this study was to investigate whether vitamin C supplementation prevents high-intensity intermittent endurance training-induced mitochondrial biogenesis in the skeletal muscle. Male Wistar-strain rats were assigned to one of five groups: a control group, training group, small dose vitamin C supplemented training group, middle dose vitamin C supplemented training group, and large dose vitamin C supplemented training group. The rats of the trained groups were subjected to intense intermittent swimming training. The vitamin C supplemented groups were administrated vitamin C for the pretraining and training periods. High-intensity intermittent swimming training without vitamin C supplementation significantly increased peroxisome proliferator-activated receptor-γ coactivator-1α protein content and citrate synthase activity in the epitrochlearis muscle. The vitamin C supplementation did not alter the training-induced increase of these regardless of the dose of vitamin C supplementation. The results demonstrate that vitamin C supplementation does not prevent high-intensity intermittent training-induced mitochondrial biogenesis in the skeletal muscle.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalJournal of Physiological Sciences
Volume64
Issue number2
DOIs
Publication statusPublished - 2014

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Organelle Biogenesis
Ascorbic Acid
Muscles
Skeletal Muscle
Citrate (si)-Synthase
Peroxisome Proliferator-Activated Receptors
Wistar Rats
Control Groups

Keywords

  • Antioxidant
  • High intensity intermittent exercise
  • Peroxisome proliferator-activated receptor γ coactivator-1α
  • Reactive oxygen species

ASJC Scopus subject areas

  • Physiology

Cite this

Vitamin C supplementation does not alter high-intensity endurance training-induced mitochondrial biogenesis in rat epitrochlearis muscle. / Yada, Koichi; Matoba, Hideki.

In: Journal of Physiological Sciences, Vol. 64, No. 2, 2014, p. 113-118.

Research output: Contribution to journalArticle

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