Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito, Masami Miura, Hidekazu Furuse, Chen Zhixiong, Hiroshi Kato, Daisuke Yasutomi, Takafumi Inoue, Katsuhiko Mikoshiba, Tetsutoshi Kimura, Shunpei Sakakibara, Hiroyoshi Miyakawa

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Abstract

It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

Original languageEnglish
Pages (from-to)112-115
Number of pages4
JournalNeuroscience Letters
Volume183
Issue number1-2
DOIs
Publication statusPublished - 1995 Jan 2

Keywords

  • 2-Amino-5-phosphonovalerate
  • Ca channels
  • Hippocampus
  • Long-term potentiation
  • Nickel
  • ω-AgaIVA

ASJC Scopus subject areas

  • Neuroscience(all)

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    Ito, K. I., Miura, M., Furuse, H., Zhixiong, C., Kato, H., Yasutomi, D., Inoue, T., Mikoshiba, K., Kimura, T., Sakakibara, S., & Miyakawa, H. (1995). Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. Neuroscience Letters, 183(1-2), 112-115. https://doi.org/10.1016/0304-3940(94)11127-5