Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons

Ken ichi Ito, Masami Miura, Hidekazu Furuse, Chen Zhixiong, Hiroshi Kato, Daisuke Yasutomi, Takafumi Inoue, Katsuhiko Mikoshiba, Tetsutoshi Kimura, Shunpei Sakakibara, Hiroyoshi Miyakawa

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+];) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltagegated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by θ-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+, (25 μM, T -channel blocker) or ω-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the Θ-burst induced UP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.

Original languageEnglish
Pages (from-to)112-115
Number of pages4
JournalNeuroscience Letters
Volume183
Issue number1-2
DOIs
Publication statusPublished - 1995 Jan 2
Externally publishedYes

Fingerprint

Long-Term Potentiation
Guinea Pigs
Neurons
Synaptic Transmission
Calcium

Keywords

  • 2-Amino-5-phosphonovalerate
  • Ca channels
  • Hippocampus
  • Long-term potentiation
  • Nickel
  • ω-AgaIVA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. / Ito, Ken ichi; Miura, Masami; Furuse, Hidekazu; Zhixiong, Chen; Kato, Hiroshi; Yasutomi, Daisuke; Inoue, Takafumi; Mikoshiba, Katsuhiko; Kimura, Tetsutoshi; Sakakibara, Shunpei; Miyakawa, Hiroyoshi.

In: Neuroscience Letters, Vol. 183, No. 1-2, 02.01.1995, p. 112-115.

Research output: Contribution to journalArticle

Ito, KI, Miura, M, Furuse, H, Zhixiong, C, Kato, H, Yasutomi, D, Inoue, T, Mikoshiba, K, Kimura, T, Sakakibara, S & Miyakawa, H 1995, 'Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons', Neuroscience Letters, vol. 183, no. 1-2, pp. 112-115. https://doi.org/10.1016/0304-3940(94)11127-5
Ito, Ken ichi ; Miura, Masami ; Furuse, Hidekazu ; Zhixiong, Chen ; Kato, Hiroshi ; Yasutomi, Daisuke ; Inoue, Takafumi ; Mikoshiba, Katsuhiko ; Kimura, Tetsutoshi ; Sakakibara, Shunpei ; Miyakawa, Hiroyoshi. / Voltage-gated Ca2+ channel blockers, ω-AgalVA and Ni2+, suppress the induction of θ-burst induced long-term potentiation in guinea-pig hippocampal CA1 neurons. In: Neuroscience Letters. 1995 ; Vol. 183, No. 1-2. pp. 112-115.
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