Walking nanothermometers: Spatiotemporal temperature measurement of transported acidic organelles in single living cells

Kotaro Oyama, Masao Takabayashi, Yoshiaki Takei, Satoshi Arai, Shinji Takeoka, Shin'Ichi Ishiwata, Madoka Suzuki

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We fabricated fluorescent nanoparticles which monitor temperature changes without sensitivity to pH (4-10) and ionic strength (0-500 mM). The nanothermometers spontaneously enter living HeLa cells via endocytosis, enclosed in acidic organelles, i.e., endosome/lysosome, and then transported along microtubules in a temperature-dependent manner, working as "walking nanothermometers".

Original languageEnglish
Pages (from-to)1591-1593
Number of pages3
JournalLab on a Chip
Volume12
Issue number9
DOIs
Publication statusPublished - 2012 May 7

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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