Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums

Musan Zhang, Sean T. Hemp, Mingqiang Zhang, Michael H. Allen, Richard N. Carmean, Robert B. Moore, Timothy Edward Long

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Novel trialkylphosphonium ionic liquids chain extenders enabled the successful synthesis of poly(ethylene glycol)-based, cationic polyurethanes with pendant phosphoniums in the hard segments (HS). Aqueous size exclusion chromatography (SEC) confirmed the charged polyurethanes, which varied the phosphonium alkyl substituent length (ethyl and butyl) and cationic HS content (25, 50, 75 mol%), achieved high absolute molecular weights. Dynamic mechanical analysis (DMA) demonstrated the triethylphosphonium (TEP) and tributylphosphonium (TBP) polyurethanes displayed similar thermomechanical properties, including increased rubbery plateau moduli and flow temperatures. Fourier transform infrared spectroscopy (FTIR) emphasized the significance of ion-dipole interaction on hydrogen bonding. Atomic force microscopy (AFM), small-angle X-ray scattering (SAXS), and wide-angle X-ray diffraction (WAXD) supported microphase separated morphologies in the trialkylphosphonium polyurethanes, despite the presence of ionic interactions. Sorption isotherm experiments revealed the TEP polyurethane exhibited the highest water vapor sorption profile compared to the TBP, which displayed similar water sorption profiles to the noncharged analogue. The phosphonium polyurethanes displayed significantly improved tensile strain; however, lower tensile stress of the TEP polyurethane was presumably due to absorbed water. In addition to physical characterizations, we also explored the trialkylphosphonium polyurethanes as nucleic acid delivery vectors. The phosphonium polyurethanes bound DNA at low charge ratios, and the polyplexes exhibited enhanced colloidal stability under physiological salt conditions.

Original languageEnglish
Pages (from-to)3795-3803
Number of pages9
JournalPolymer Chemistry
Volume5
Issue number12
DOIs
Publication statusPublished - 2014 Jun 21
Externally publishedYes

Fingerprint

Polyurethanes
Water
Sorption
Ionic Liquids
Ethylene Glycol
Size exclusion chromatography
Tensile strain
Atomic Force Microscopy
Nucleic acids
Steam
Dynamic mechanical analysis
Fourier Transform Infrared Spectroscopy
Hydrogen Bonding
X ray scattering
Ionic liquids
Tensile stress
X-Ray Diffraction
Water vapor
Nucleic Acids
Polyethylene glycols

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Zhang, M., Hemp, S. T., Zhang, M., Allen, M. H., Carmean, R. N., Moore, R. B., & Long, T. E. (2014). Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums. Polymer Chemistry, 5(12), 3795-3803. https://doi.org/10.1039/c3py01779f

Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums. / Zhang, Musan; Hemp, Sean T.; Zhang, Mingqiang; Allen, Michael H.; Carmean, Richard N.; Moore, Robert B.; Long, Timothy Edward.

In: Polymer Chemistry, Vol. 5, No. 12, 21.06.2014, p. 3795-3803.

Research output: Contribution to journalArticle

Zhang, M, Hemp, ST, Zhang, M, Allen, MH, Carmean, RN, Moore, RB & Long, TE 2014, 'Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums', Polymer Chemistry, vol. 5, no. 12, pp. 3795-3803. https://doi.org/10.1039/c3py01779f
Zhang M, Hemp ST, Zhang M, Allen MH, Carmean RN, Moore RB et al. Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums. Polymer Chemistry. 2014 Jun 21;5(12):3795-3803. https://doi.org/10.1039/c3py01779f
Zhang, Musan ; Hemp, Sean T. ; Zhang, Mingqiang ; Allen, Michael H. ; Carmean, Richard N. ; Moore, Robert B. ; Long, Timothy Edward. / Water-dispersible cationic polyurethanes containing pendant trialkylphosphoniums. In: Polymer Chemistry. 2014 ; Vol. 5, No. 12. pp. 3795-3803.
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