TY - JOUR
T1 - Wide-band X-ray and gamma-ray imaging of living mouse to reveal pharmacokinetics of At-211
AU - Masubuchi, M.
AU - Omata, A.
AU - Koshikawa, N.
AU - Kataoka, J.
AU - Kato, H.
AU - Toyoshima, A.
AU - Ooe, K.
AU - Katayama, D.
AU - Teramoto, T.
AU - Matsunaga, K.
AU - Kamiya, T.
AU - Watabe, T.
AU - Shimosegawa, E.
AU - Hatazawa, J.
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Nuclear medicine therapy is a treatment method in which a radionuclide-labeled agent is selectively taken up by the lesion, and a tumor is directly irradiated. In particular, At-211, which is an alpha-ray-emitting nuclide and is expected to be highly effective with few side effects, has attracted attention in recent years. In actual treatment, real-time monitoring is required to confirm the dynamics of drug accumulation at the correct location and to estimate the exposure of normal tissues; therefore, accurate imaging technology is required. We used a hybrid Compton camera (HCC), which is capable of broadband imaging, from characteristic X-rays to nuclear gamma rays, to image mice treated with At-211 NaAt. Four HCCs were used to image the At-211 NaAt-injected mouse under anesthesia. As a result, we were able to observe 3D pharmacokinetics in the living mouse by using 79 keV X-rays, and the accumulation of At-211 NaAt in the stomach and thyroid. By implementing the BGO active shield, we also succeeded in visualizing the drug distribution of At-211 NaAt in the mouse using nuclear gamma rays of 570 keV for the first time.
AB - Nuclear medicine therapy is a treatment method in which a radionuclide-labeled agent is selectively taken up by the lesion, and a tumor is directly irradiated. In particular, At-211, which is an alpha-ray-emitting nuclide and is expected to be highly effective with few side effects, has attracted attention in recent years. In actual treatment, real-time monitoring is required to confirm the dynamics of drug accumulation at the correct location and to estimate the exposure of normal tissues; therefore, accurate imaging technology is required. We used a hybrid Compton camera (HCC), which is capable of broadband imaging, from characteristic X-rays to nuclear gamma rays, to image mice treated with At-211 NaAt. Four HCCs were used to image the At-211 NaAt-injected mouse under anesthesia. As a result, we were able to observe 3D pharmacokinetics in the living mouse by using 79 keV X-rays, and the accumulation of At-211 NaAt in the stomach and thyroid. By implementing the BGO active shield, we also succeeded in visualizing the drug distribution of At-211 NaAt in the mouse using nuclear gamma rays of 570 keV for the first time.
KW - 3D imaging
KW - Broad-band imaging
KW - Compton camera
KW - Pharmacokinetics
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U2 - 10.1016/j.nima.2022.167581
DO - 10.1016/j.nima.2022.167581
M3 - Article
AN - SCOPUS:85145352600
VL - 1045
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
SN - 0168-9002
M1 - 167581
ER -