Wide-band X-ray and gamma-ray imaging of living mouse to reveal pharmacokinetics of At-211

M. Masubuchi*, A. Omata, N. Koshikawa, J. Kataoka, H. Kato, A. Toyoshima, K. Ooe, D. Katayama, T. Teramoto, K. Matsunaga, T. Kamiya, T. Watabe, E. Shimosegawa, J. Hatazawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear medicine therapy is a treatment method in which a radionuclide-labeled agent is selectively taken up by the lesion, and a tumor is directly irradiated. In particular, At-211, which is an alpha-ray-emitting nuclide and is expected to be highly effective with few side effects, has attracted attention in recent years. In actual treatment, real-time monitoring is required to confirm the dynamics of drug accumulation at the correct location and to estimate the exposure of normal tissues; therefore, accurate imaging technology is required. We used a hybrid Compton camera (HCC), which is capable of broadband imaging, from characteristic X-rays to nuclear gamma rays, to image mice treated with At-211 NaAt. Four HCCs were used to image the At-211 NaAt-injected mouse under anesthesia. As a result, we were able to observe 3D pharmacokinetics in the living mouse by using 79 keV X-rays, and the accumulation of At-211 NaAt in the stomach and thyroid. By implementing the BGO active shield, we also succeeded in visualizing the drug distribution of At-211 NaAt in the mouse using nuclear gamma rays of 570 keV for the first time.

Keywords

  • 3D imaging
  • Broad-band imaging
  • Compton camera
  • Pharmacokinetics

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation

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