YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

Fumito Koizumi, Naomi Fukumitsu, Jinrong Zhao, Ruthada Chanklan, Tokichi Miyakawa, Shoko Kawahara, Shin Iwamoto, Makoto Suzuki, Shingo Kakita, Endang S. Rahayu, Seijiro Hosokawa, Kuniaki Tatsuta, Michio Ichimura

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

    Original languageEnglish
    Pages (from-to)455-458
    Number of pages4
    JournalJournal of Antibiotics
    Volume60
    Issue number7
    DOIs
    Publication statusPublished - 2007 Jul

    Fingerprint

    Fusarium
    Preclinical Drug Evaluations
    Growth
    Fermentation
    Saccharomyces cerevisiae
    Chromatography
    Yeasts
    High Pressure Liquid Chromatography
    YCM 1008A

    Keywords

    • Ca-signaling
    • Fusarium
    • Pyrano-pyridone
    • YCM1008A
    • Yeast

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery
    • Molecular Medicine

    Cite this

    Koizumi, F., Fukumitsu, N., Zhao, J., Chanklan, R., Miyakawa, T., Kawahara, S., ... Ichimura, M. (2007). YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. Journal of Antibiotics, 60(7), 455-458. https://doi.org/10.1038/ja.2007.58

    YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. / Koizumi, Fumito; Fukumitsu, Naomi; Zhao, Jinrong; Chanklan, Ruthada; Miyakawa, Tokichi; Kawahara, Shoko; Iwamoto, Shin; Suzuki, Makoto; Kakita, Shingo; Rahayu, Endang S.; Hosokawa, Seijiro; Tatsuta, Kuniaki; Ichimura, Michio.

    In: Journal of Antibiotics, Vol. 60, No. 7, 07.2007, p. 455-458.

    Research output: Contribution to journalArticle

    Koizumi, F, Fukumitsu, N, Zhao, J, Chanklan, R, Miyakawa, T, Kawahara, S, Iwamoto, S, Suzuki, M, Kakita, S, Rahayu, ES, Hosokawa, S, Tatsuta, K & Ichimura, M 2007, 'YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008', Journal of Antibiotics, vol. 60, no. 7, pp. 455-458. https://doi.org/10.1038/ja.2007.58
    Koizumi F, Fukumitsu N, Zhao J, Chanklan R, Miyakawa T, Kawahara S et al. YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. Journal of Antibiotics. 2007 Jul;60(7):455-458. https://doi.org/10.1038/ja.2007.58
    Koizumi, Fumito ; Fukumitsu, Naomi ; Zhao, Jinrong ; Chanklan, Ruthada ; Miyakawa, Tokichi ; Kawahara, Shoko ; Iwamoto, Shin ; Suzuki, Makoto ; Kakita, Shingo ; Rahayu, Endang S. ; Hosokawa, Seijiro ; Tatsuta, Kuniaki ; Ichimura, Michio. / YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. In: Journal of Antibiotics. 2007 ; Vol. 60, No. 7. pp. 455-458.
    @article{a1f9bf44cc494c77abccfd5f7984608d,
    title = "YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008",
    abstract = "In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.",
    keywords = "Ca-signaling, Fusarium, Pyrano-pyridone, YCM1008A, Yeast",
    author = "Fumito Koizumi and Naomi Fukumitsu and Jinrong Zhao and Ruthada Chanklan and Tokichi Miyakawa and Shoko Kawahara and Shin Iwamoto and Makoto Suzuki and Shingo Kakita and Rahayu, {Endang S.} and Seijiro Hosokawa and Kuniaki Tatsuta and Michio Ichimura",
    year = "2007",
    month = "7",
    doi = "10.1038/ja.2007.58",
    language = "English",
    volume = "60",
    pages = "455--458",
    journal = "Journal of Antibiotics",
    issn = "0021-8820",
    publisher = "Japan Antibiotics Research Association",
    number = "7",

    }

    TY - JOUR

    T1 - YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

    AU - Koizumi, Fumito

    AU - Fukumitsu, Naomi

    AU - Zhao, Jinrong

    AU - Chanklan, Ruthada

    AU - Miyakawa, Tokichi

    AU - Kawahara, Shoko

    AU - Iwamoto, Shin

    AU - Suzuki, Makoto

    AU - Kakita, Shingo

    AU - Rahayu, Endang S.

    AU - Hosokawa, Seijiro

    AU - Tatsuta, Kuniaki

    AU - Ichimura, Michio

    PY - 2007/7

    Y1 - 2007/7

    N2 - In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

    AB - In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

    KW - Ca-signaling

    KW - Fusarium

    KW - Pyrano-pyridone

    KW - YCM1008A

    KW - Yeast

    UR - http://www.scopus.com/inward/record.url?scp=38449101721&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=38449101721&partnerID=8YFLogxK

    U2 - 10.1038/ja.2007.58

    DO - 10.1038/ja.2007.58

    M3 - Article

    C2 - 17721004

    AN - SCOPUS:38449101721

    VL - 60

    SP - 455

    EP - 458

    JO - Journal of Antibiotics

    JF - Journal of Antibiotics

    SN - 0021-8820

    IS - 7

    ER -