YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008

Fumito Koizumi, Naomi Fukumitsu, Jinrong Zhao, Ruthada Chanklan, Tokichi Miyakawa, Shoko Kawahara, Shin Iwamoto, Makoto Suzuki, Shingo Kakita, Endang S. Rahayu, Seijiro Hosokawa, Kuniaki Tatsuta, Michio Ichimura

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1

Keywords

  • Ca-signaling
  • Fusarium
  • Pyrano-pyridone
  • YCM1008A
  • Yeast

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Koizumi, F., Fukumitsu, N., Zhao, J., Chanklan, R., Miyakawa, T., Kawahara, S., Iwamoto, S., Suzuki, M., Kakita, S., Rahayu, E. S., Hosokawa, S., Tatsuta, K., & Ichimura, M. (2007). YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. Journal of Antibiotics, 60(7), 455-458. https://doi.org/10.1038/ja.2007.58