yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family

Kentaro Senba, M. Nishizawa, N. Miyajima, M. C. Yoshida, J. Sukegawa, Y. Yamanashi, M. Sasaki, T. Yamamoto, K. Toyoshima

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.

Original languageEnglish
Pages (from-to)5459-5463
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number15
DOIs
Publication statusPublished - 1986
Externally publishedYes

Fingerprint

Protein-Tyrosine Kinases
Genes
src Genes
Chromosomes, Human, Pair 6
Molecular Cloning
Human Genome
Oncogenes
Terminology
Sequence Analysis
Complementary DNA
Clone Cells

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family. / Senba, Kentaro; Nishizawa, M.; Miyajima, N.; Yoshida, M. C.; Sukegawa, J.; Yamanashi, Y.; Sasaki, M.; Yamamoto, T.; Toyoshima, K.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 15, 1986, p. 5459-5463.

Research output: Contribution to journalArticle

Senba, K, Nishizawa, M, Miyajima, N, Yoshida, MC, Sukegawa, J, Yamanashi, Y, Sasaki, M, Yamamoto, T & Toyoshima, K 1986, 'yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family', Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 15, pp. 5459-5463. https://doi.org/10.1073/pnas.83.15.5459
Senba, Kentaro ; Nishizawa, M. ; Miyajima, N. ; Yoshida, M. C. ; Sukegawa, J. ; Yamanashi, Y. ; Sasaki, M. ; Yamamoto, T. ; Toyoshima, K. / yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family. In: Proceedings of the National Academy of Sciences of the United States of America. 1986 ; Vol. 83, No. 15. pp. 5459-5463.
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abstract = "An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.",
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AU - Yoshida, M. C.

AU - Sukegawa, J.

AU - Yamanashi, Y.

AU - Sasaki, M.

AU - Yamamoto, T.

AU - Toyoshima, K.

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