yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family

K. Semba, M. Nishizawa, N. Miyajima, M. C. Yoshida, J. Sukegawa, Y. Yamanashi, M. Sasaki, T. Yamamoto, K. Toyoshima

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137 Citations (Scopus)


An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.

Original languageEnglish
Pages (from-to)5459-5463
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number15
Publication statusPublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • General


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