Abstract
An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.
| Original language | English |
|---|---|
| Pages (from-to) | 5459-5463 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 83 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family. / Senba, Kentaro; Nishizawa, M.; Miyajima, N.; Yoshida, M. C.; Sukegawa, J.; Yamanashi, Y.; Sasaki, M.; Yamamoto, T.; Toyoshima, K.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 15, 1986, p. 5459-5463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - yes-Related protooncogene, syn, belongs to the protein-tyrosine kinase family
AU - Senba, Kentaro
AU - Nishizawa, M.
AU - Miyajima, N.
AU - Yoshida, M. C.
AU - Sukegawa, J.
AU - Yamanashi, Y.
AU - Sasaki, M.
AU - Yamamoto, T.
AU - Toyoshima, K.
PY - 1986
Y1 - 1986
N2 - An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.
AB - An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.
UR - http://www.scopus.com/inward/record.url?scp=0022441299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022441299&partnerID=8YFLogxK
U2 - 10.1073/pnas.83.15.5459
DO - 10.1073/pnas.83.15.5459
M3 - Article
VL - 83
SP - 5459
EP - 5463
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15
ER -