YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

Eri Ikeda; Satoshi Yoshida; Hiroshi Mitsuzawa; Isao Uno; Akio Toh-e

doi:10.1016/0014-5793(94)80428-1

YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

Eri Ikeda^*, Satoshi Yoshida, Hiroshi Mitsuzawa, Isao Uno, Akio Toh-e

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	FEBS Letters
Volume	339
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(94)80428-1
Publication status	Published - 1994 Feb 21
Externally published	Yes

Keywords

Essential gene
Mitochondria
Saccharomyces cerevisiae
grpE

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/0014-5793(94)80428-1

Cite this

@article{0b8ebfda5dee434e95d85467baae42b4,

title = "YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions",

abstract = "The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.",

keywords = "Essential gene, Mitochondria, Saccharomyces cerevisiae, grpE",

author = "Eri Ikeda and Satoshi Yoshida and Hiroshi Mitsuzawa and Isao Uno and Akio Toh-e",

year = "1994",

month = feb,

day = "21",

doi = "10.1016/0014-5793(94)80428-1",

language = "English",

volume = "339",

pages = "265--268",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

AU - Ikeda, Eri

AU - Yoshida, Satoshi

AU - Mitsuzawa, Hiroshi

AU - Uno, Isao

AU - Toh-e, Akio

PY - 1994/2/21

Y1 - 1994/2/21

N2 - The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.

AB - The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.

KW - Essential gene

KW - Mitochondria

KW - Saccharomyces cerevisiae

KW - grpE

UR - http://www.scopus.com/inward/record.url?scp=0028137887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028137887&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(94)80428-1

DO - 10.1016/0014-5793(94)80428-1

M3 - Article

C2 - 8112465

AN - SCOPUS:0028137887

SN - 0014-5793

VL - 339

SP - 265

EP - 268

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this