YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions

Eri Ikeda, Satoshi Yoshida, Hiroshi Mitsuzawa, Isao Uno, Akio Toh-e

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Ygel product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Ygel protein plays a pivotal role in maintaining mitochondrial functions.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalFEBS Letters
Volume339
Issue number3
DOIs
Publication statusPublished - 1994 Feb 21
Externally publishedYes

Keywords

  • Essential gene
  • Mitochondria
  • Saccharomyces cerevisiae
  • grpE

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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