• 1027 引用
  • 13 h指数
19982019
Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1998 2019

  • 1027 引用
  • 13 h指数
  • 36 Article
  • 4 Review article
  • 3 Conference contribution
  • 1 Chapter
2019

Comparison between effects of retroactivity and resource competition upon change in downstream reporter genes of synthetic genetic circuits

Moriya, T., Yamaoka, T., Wakayama, Y., Ayukawa, S., Zhang, Z., Yamamura, M., Wakao, S. & Kiga, D., 2019 3 1, : : Life. 9, 1, 30.

研究成果: Article

公開
Reporter Genes
reporter genes
genes
Computer Simulation
resources

Enhancement of binding affinity of folate to its receptor by peptide conjugation

Dharmatti, R., Miyatake, H., Nandakumar, A., Ueda, M., Kobayashi, K., Kiga, D., Yamamura, M. & Ito, Y., 2019 5 1, : : International journal of molecular sciences. 20, 9, 2152.

研究成果: Article

公開
Peptide Receptors
conjugation
Folic Acid
Peptides
peptides

RNA world

Ayukawa, S., Enomoto, T. & Kiga, D., 2019 1 1, Astrobiology: From the Origins of Life to the Search for Extraterrestrial Intelligence. Springer Singapore, p. 77-90 14 p.

研究成果: Chapter

Catalytic RNA
RNA
proteins
peptides
protein
2018

A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b

Imada, T., Moriya, K., Uchiyama, M., Inukai, N., Hitotsuyanagi, M., Masuda, A., Suzuki, T., Ayukawa, S., Tagawa, Y. I., Dohmae, N., Kohara, M., Yamamura, M. & Kiga, D., 2018 1 1, (Accepted/In press) : : ACS Synthetic Biology.

研究成果: Article

Interferons
Bioactivity
Proteins
Antiviral Agents
Pharmacokinetics
1 引用 (Scopus)

Escherichia coli expression, purification, and refolding of human folate receptor α (hFRα) and β (hFRβ)

Dharmatti, R., Miyatake, H., Zhang, C., Ren, X., Yumoto, A., Kiga, D., Yamamura, M. & Ito, Y., 2018 9 1, : : Protein Expression and Purification. 149, p. 17-22 6 p.

研究成果: Article

Folic Acid
Escherichia coli
Inclusion Bodies
Disulfides
Prokaryotic Cells
2 引用 (Scopus)

Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent

Froese, T., Campos, J. I., Fujishima, K., Kiga, D. & Virgo, N., 2018 12 1, : : Scientific Reports. 8, 1, 3532.

研究成果: Article

Artificial Cells
Aminoacylation
Genetic Code
Amino Acyl-tRNA Synthetases
Catalytic RNA
2017
2 引用 (Scopus)
irinotecan
Pharmacokinetics
Perturbation Analysis
Newton-Raphson method
Newton Methods
2016
1 引用 (Scopus)

A bacterial continuous culture system based on a microfluidic droplet open reactor

Ito, M., Sugiura, H., Ayukawa, S., Kiga, D. & Takinoue, M., 2016, : : Analytical Sciences. 32, 1, p. 61-66 6 p.

研究成果: Article

Microfluidics
Fusion reactions
Metabolic engineering
Nutrients
Oils

High-frequency noise attenuation of a two-component system responding to short-pulse input

Nishida, A., Sekine, R., Kiga, D. & Yamamura, M., 2016 12 19, Proceedings of the 2016 7th International Conference on Computational Systems-Biology and Bioinformatics, CSBio 2016. Association for Computing Machinery, 巻 Part F126331. p. 28-35 8 p.

研究成果: Conference contribution

Phosphorylation
Light modulation
Sensors
Gene expression
Reaction rates
16 引用 (Scopus)

Reproducibility of fluorescent expression from engineered biological constructs in E. coli

iGEM Interlab Study Contributors, 2016 3 1, : : PLoS One. 11, 3, e0150182.

研究成果: Article

reproducibility
Escherichia coli
Fluorescence
promoter regions
fluorescence
2015
3 引用 (Scopus)

In vitro selection of a photoresponsive peptide aptamer to glutathione-immobilized microbeads

Tada, S., Zang, Q., Wang, W., Kawamoto, M., Liu, M., Iwashita, M., Uzawa, T., Kiga, D., Yamamura, M. & Ito, Y., 2015 2 1, : : Journal of Bioscience and Bioengineering. 119, 2, p. 137-139 3 p.

研究成果: Article

Peptide Aptamers
Amino Acid-Specific Transfer RNA
Azobenzene
Transfer RNA
Microspheres
4 引用 (Scopus)

Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide

Zang, Q., Tada, S., Uzawa, T., Kiga, D., Yamamura, M. & Ito, Y., 2015 7 31, : : Chemical Communications. 51, 76, p. 14385-14388 4 p.

研究成果: Article

Anticodon
Peptides
Polyethylene glycols
Polypeptides
Transfer RNA
2014
Genetic engineering
Animals
Networks (circuits)
Computer simulation
Observation
Escherichia coli
Artificial Cells
Calcium Carbonate
Regeneration
4 引用 (Scopus)

Effects of downstream genes on synthetic genetic circuits

Moriya, T., Yamamura, M. & Kiga, D., 2014 12 8, : : BMC Systems Biology. 8, 4, S4.

研究成果: Article

Synthetic Genes
Synthetic Biology
Genes
Gene
Networks (circuits)

Experimental Evolution of a Green Fluorescent Protein Composed of 19 Unique Amino Acids without Tryptophan

Kawahara-Kobayashi, A., Hitotsuyanagi, M., Amikura, K. & Kiga, D., 2014 12 11, : : Origins of Life and Evolution of the Biosphere. 44, 2, p. 75-86 12 p.

研究成果: Article

tryptophan
Green Fluorescent Proteins
green fluorescent protein
Tryptophan
amino acids
5 引用 (Scopus)

General Applicability of Synthetic Gene-Overexpression for Cell-Type Ratio Control via Reprogramming

Ishimatsu, K., Hata, T., Mochizuki, A., Sekine, R., Yamamura, M. & Kiga, D., 2014 9 19, : : ACS Synthetic Biology. 3, 9, p. 638-644 7 p.

研究成果: Article

Synthetic Genes
Genes
Escherichia coli
Switches
Molecules
5 引用 (Scopus)

Multiple amino acid-excluded genetic codes for protein engineering using multiple sets of tRNA variants

Amikura, K., Sakai, Y., Asami, S. & Kiga, D., 2014 3 21, : : ACS Synthetic Biology. 3, 3, p. 140-144 5 p.

研究成果: Article

Genetic Code
Protein Engineering
Transfer RNA
Amino acids
Proteins

Why 20 amino acids?

Amikura, K. & Kiga, D., 2014, : : Kobunshi. 63, 6, p. 392-393 2 p.

研究成果: Article

Amino acids
Amino Acids
Proteins
Biochemistry
Alanine
2013

Cultivation of synthetic biology with the iGEM competition

Thamamongood, T., Lim, N. Z. L., Ho, T. Y. H., Ayukawa, S., Kiga, D. & Chow, K. L., 2013 3, : : Journal of Advanced Computational Intelligence and Intelligent Informatics. 17, 2, p. 161-166 6 p.

研究成果: Review article

Students
Agriculture
Medicine
Engineers
Synthetic Biology

Synthetic biology and dual use

Kiga, D., 2013, : : Journal of Disaster Research. 8, 4, p. 698-704 7 p.

研究成果: Review article

Genes
Synthetic Biology
Innovation
Experiments
2 引用 (Scopus)

The number of amino acids in a genetic code

Amikura, K. & Kiga, D., 2013 8 21, : : RSC Advances. 3, 31, p. 12512-12517 6 p.

研究成果: Review article

Amino acids
Amino Acids
Proteins
Drug products
Pharmaceutical Preparations
2012
13 引用 (Scopus)

An aptazyme-based molecular device that converts a small-molecule input into an RNA output

Ayukawa, S., Sakai, Y. & Kiga, D., 2012 8 7, : : Chemical Communications. 48, 61, p. 7556-7558 3 p.

研究成果: Article

RNA
Molecules
Nucleic acids
Nucleic Acids
14 引用 (Scopus)

Simplification of the genetic code: Restricted diversity of genetically encoded amino acids

Kawahara-Kobayashi, A., Masuda, A., Araiso, Y., Sakai, Y., Kohda, A., Uchiyama, M., Asami, S., Matsuda, T., Ishitani, R., Dohmae, N., Yokoyama, S., Kigawa, T., Nureki, O. & Kiga, D., 2012 11, : : Nucleic Acids Research. 40, 20, p. 10576-10584 9 p.

研究成果: Article

Genetic Code
Amino Acids
RNA, Transfer, Ala
Anticodon
Protein Engineering
generators (equipment)
Acyl-Butyrolactones
cells
homoserine
lactones
2011
19 引用 (Scopus)

RTRACS: A modularized RNA-dependent RNA transcription system with high programmability

Ayukawa, S., Takinoue, M. & Kiga, D., 2011 12 20, : : Accounts of Chemical Research. 44, 12, p. 1369-1379 11 p.

研究成果: Article

Transcription
Biological systems
RNA
Large scale systems
Mathematical models
23 引用 (Scopus)

Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling

Sekine, R., Yamamura, M., Ayukawa, S., Ishimatsu, K., Akama, S., Takinoue, M., Hagiya, M. & Kiga, D., 2011 11 1, : : Proceedings of the National Academy of Sciences of the United States of America. 108, 44, p. 17969-17973 5 p.

研究成果: Article

Cell Count
Calcium Carbonate
Tissue Engineering
Cell Communication
Computer Simulation
2010
10 引用 (Scopus)

Construction of a genetic AND gate under a new standard for assembly of genetic parts

Ayukawa, S., Kobayashi, A., Nakashima, Y., Takagi, H., Hamada, S., Uchiyama, M., Yugi, K., Murata, S., Sakakibara, Y., Hagiya, M., Yamamura, M. & Kiga, D., 2010 12 2, : : BMC Genomics. 11, SUPPL. 4, S16.

研究成果: Article

operator regions
Logic gates
Nucleic Acid Regulatory Sequences
Gene expression
Plasmids
2009
7 引用 (Scopus)

Rna oscillator: Limit cycle oscillations based on artificial biomolecular reactions

Takinoue, M., Kiga, D., Shohda, K. I. & Suyama, A., 2009 2, : : New Generation Computing. 27, 2, p. 107-127 21 p.

研究成果: Article

Limit Cycle
RNA
DNA
Oscillation
Degradation
2008
1 引用 (Scopus)
DNA
Enzymes
Stators
Molecular biology
Computer simulation
4 引用 (Scopus)

A realization of DNA molecular machine that walks autonomously by using a restriction enzyme

Sekiguchi, H., Komiya, K., Kiga, D. & Yamamura, M., 2008, DNA Computing - 13th International Meeting on DNA Computing, DNA13, Revised Selected Papers. 巻 4848 LNCS. p. 54-65 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻数 4848 LNCS).

研究成果: Conference contribution

Walk
Walking
Enzymes
DNA
Restriction
35 引用 (Scopus)
Molecular Computing
Transcription
Simulation Model
Experiment
Reverse
1 引用 (Scopus)

Synthetic biology

Kiga, D. & Yamamura, M., 2008 8, : : New Generation Computing. 26, 4, p. 347-364 18 p.

研究成果: Article

Synthetic Biology
Molecular biology
Systems science
Molecular Biology
Biology
2007

Oscillator for self-assembled DNA nanomachines

Takinoue, M., Kiga, D., Shohda, K. I. & Suyama, A., 2007, 4th Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2007. p. 104-106 3 p.

研究成果: Conference contribution

RNA
DNA
Nucleic acids
Differential equations
Feedback
2 引用 (Scopus)

SYANAC: SYnthetic biological Automaton for Noughts and Crosses

Ayukawa, S., Kobayashi, A., Nakashima, Y., Takagi, H., Hamada, S., Uchiyama, M., Yugi, K., Murata, S., Sakakibara, Y., Hagiya, M., Yamamura, M. & Kiga, D., 2007, : : IET Synthetic Biology. 1, 1-2, p. 64-67 4 p.

研究成果: Article

Logic gates
Protein Binding
Binding sites
Genes
Binding Sites
2006
57 引用 (Scopus)

Cation-π interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase

Morikubo, N., Fukuda, Y., Ohtake, K., Shinya, N., Kiga, D., Sakamoto, K., Asanuma, M., Hirota, H., Yokoyama, S. & Hoshino, T., 2006 10 11, : : Journal of the American Chemical Society. 128, 40, p. 13184-13194 11 p.

研究成果: Article

Cyclization
Polyolefins
Cations
Amino acids
Catalytic Domain
19 引用 (Scopus)

DNA polymerase programmed with a hairpin DNA incorporates a multiple-instruction architecture into molecular computing

Komiya, K., Sakamoto, K., Kameda, A., Yamamoto, M., Ohuchi, A., Kiga, D., Yokoyama, S. & Hagiya, M., 2006 1, : : BioSystems. 83, 1, p. 18-25 8 p.

研究成果: Article

Molecular Computing
DNA-directed DNA polymerase
DNA-Directed DNA Polymerase
Hamiltonians
DNA
21 引用 (Scopus)

Translation of 'rare' codons in a cell-free protein synthesis system from Escherichia coli

Chumpolkulwong, N., Sakamoto, K., Hayashi, A., Iraha, F., Shinya, N., Matsuda, N., Kiga, D., Urushibata, A., Shirouzu, M., Oki, K., Kigawa, T. & Yokoyama, S., 2006 3, : : Journal of Structural and Functional Genomics. 7, 1, p. 31-36 6 p.

研究成果: Article

Codon
Escherichia coli
Bearings (structural)
Genes
Proteins
2002
135 引用 (Scopus)

An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system

Kiga, D., Sakamoto, K., Kodama, K., Kigawa, T., Matsuda, T., Yabuki, T., Shirouzu, M., Harada, Y., Nakayama, H., Takio, K., Hasegawa, Y., Endo, Y., Hirao, I. & Yokoyama, S., 2002 7 23, : : Proceedings of the National Academy of Sciences of the United States of America. 99, 15, p. 9715-9720 6 p.

研究成果: Article

Tyrosine-tRNA Ligase
Cell-Free System
Germ Cells
Triticum
Escherichia coli
171 引用 (Scopus)

Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells

Sakamoto, K., Hayashi, A., Sakamoto, A., Kiga, D., Nakayama, H., Soma, A., Kobayashi, T., Kitabatake, M., Takio, K., Saito, K., Shirouzu, M., Hirao, I. & Yokoyama, S., 2002 11 1, : : Nucleic Acids Research. 30, 21, p. 4692-4699 8 p.

研究成果: Article

Tyrosine-tRNA Ligase
RNA, Transfer, Tyr
Amino Acids
Transfer RNA
Amber
2001
6 引用 (Scopus)
Arginine-tRNA Ligase
Anticodon
Transfer RNA
Escherichia coli
RNA, Transfer, Arg
2000
315 引用 (Scopus)

Molecular computation by DNA hairpin formation

Sakamoto, K., Gouzu, H., Komiya, K., Kiga, D., Yokoyama, S., Yokomori, T. & Hagiya, M., 2000 5 19, : : Science. 288, 5469, p. 1223-1226 4 p.

研究成果: Article

Molecular Computers
Single-Stranded DNA
Molecular Biology
DNA
1999
69 引用 (Scopus)

State transitions by molecules

Sakamoto, K., Kiga, D., Komiya, K., Gouzu, H., Yokoyama, S., Ikeda, S., Sugiyama, H. & Hagiya, M., 1999 10, : : BioSystems. 52, 1-3, p. 81-91 11 p.

研究成果: Article

State Transition
State Machine
DNA
Molecules
Single-Stranded DNA
1998
60 引用 (Scopus)

An RNA aptamer to the xanthine/guanine base with a distinctive mode of purine recognition

Kiga, D., Futamura, Y., Sakamoto, K. & Yokoyama, S., 1998 4 1, : : Nucleic Acids Research. 26, 7, p. 1755-1760 6 p.

研究成果: Article

Nucleotide Aptamers
Xanthine
Guanine
RNA
Consensus Sequence