• 4484 引用
  • 41 h指数
1990 …2019
Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1990 2019

  • 4484 引用
  • 41 h指数
  • 171 Article
  • 7 Conference contribution
  • 3 Comment/debate
  • 2 Chapter
2019

A CCR5 + memory subset within HIV-1-infected primary resting CD4 + T cells is permissive for replication-competent, latently infected viruses in vitro

Terahara, K., Iwabuchi, R., Hosokawa, M., Nishikawa, Y., Takeyama, H., Takahashi, Y. & Tsunetsugu-Yokota, Y., 2019 4 29, : : BMC Research Notes. 12, 1, 242.

研究成果: Article

公開
T-cells
Viruses
HIV-1
Tropics
Flow cytometry

Correction to: An estrogen antagonist, cyclofenil, has anti-dengue-virus activity (Archives of Virology, (2019), 164, 1, (225-234), 10.1007/s00705-018-4079-0)

Tohma, D., Tajima, S., Kato, F., Sato, H., Kakisaka, M., Hishiki, T., Kataoka, M., Takeyama, H., Lim, C. K., Aida, Y. & Saijo, M., 2019 1 22, : : Archives of Virology. 164, 1, 1 p.

研究成果: Comment/debate

Cyclofenil
Estrogen Antagonists
Dengue Virus
Virology
Actins
公開
T-cells
Viruses
Publications
HIV-1
T-Lymphocytes

Enrichment of bacteria and alginate lyase genes potentially involved in brown alga degradation in the gut of marine gastropods

Ito, M., Watanabe, K., Maruyama, T., Mori, T., Niwa, K., Chow, S. & Takeyama, H., 2019 12 1, : : Scientific reports. 9, 1, 2129.

研究成果: Article

Phaeophyta
Gastropoda
Oceans and Seas
Bacteria
Hares

Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Adachi, Y., Tonouchi, K., Nithichanon, A., Kuraoka, M., Watanabe, A., Shinnakasu, R., Asanuma, H., Ainai, A., Ohmi, Y., Yamamoto, T., Ishii, K. J., Hasegawa, H., Takeyama, H., Lertmemongkolchai, G., Kurosaki, T., Ato, M., Kelsoe, G. & Takahashi, Y., 2019 12 1, : : Nature communications. 10, 1, 3883.

研究成果: Article

公開
influenza
Hemagglutinins
antibodies
Human Influenza
Epitopes

High-throughput identification of peptide agonists against GPCRs by co-culture of mammalian reporter cells and peptide-secreting yeast cells using droplet microfluidics

Yaginuma, K., Aoki, W., Miura, N., Ohtani, Y., Aburaya, S., Kogawa, M., Nishikawa, Y., Hosokawa, M., Takeyama, H. & Ueda, M., 2019 12 1, : : Scientific reports. 9, 1, 10920.

研究成果: Article

公開
Microfluidics
G-Protein-Coupled Receptors
Coculture Techniques
Yeasts
Ligands
2 引用 (Scopus)

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

Saito, S., Sano, K., Suzuki, T., Ainai, A., Taga, Y., Ueno, T., Tabata, K., Saito, K., Wada, Y., Ohara, Y., Takeyama, H., Odagiri, T., Kageyama, T., Ogawa-Goto, K., Multihartina, P., Setiawaty, V., Pangesti, K. N. A. & Hasegawa, H., 2019 1 1, : : PLoS Pathogens. 15, 1, p. e1007427

研究成果: Article

Secretory Immunoglobulin A
Neutralizing Antibodies
Orthomyxoviridae
Immunoglobulin A
Antibodies

Publisher Correction: A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines (Scientific Reports, (2017), 7, 1, (1283), 10.1038/s41598-017-01372-5)

Wada, Y., Nithichanon, A., Nobusawa, E., Moise, L., Martin, W. D., Yamamoto, N., Terahara, K., Hagiwara, H., Odagiri, T., Tashiro, M., Lertmemongkolchai, G., Takeyama, H., De Groot, A. S., Ato, M. & Takahashi, Y., 2019 12 1, : : Scientific reports. 9, 1, 14730.

研究成果: Comment/debate

公開
Publications
Amino Acids
Vaccine Immunogenicity

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

Matsumura, T., Ikebe, T., Arikawa, K., Hosokawa, M., Aiko, M., Iguchi, A., Togashi, I., Kai, S., Ohara, S., Ohara, N., Ohnishi, M., Watanabe, H., Kobayashi, K., Takeyama, H., Yamasaki, S., Takahashi, Y. & Ato, M., 2019 4 9, : : Cell Reports. 27, 2, p. 561-571.e6

研究成果: Article

公開
Streptococcal Infections
Myeloid Cells
Streptococcus
Interleukin-6
Infection
2018
Herpes Simplex Encephalitis
Acyclovir
Thymidine Kinase
Human Herpesvirus 1
Amino Acid Substitution

A metabarcoding survey for seasonal picophytoplankton composition in two coral reefs around Sesoko Island, Okinawa, Japan

Nuryadi, H., Nguyen, T. T. M., Ito, M., Okada, N., Wakaoji, S., Maruyama, T., Nakano, Y., Fujimura, H., Takeyama, H. & Suda, S., 2018 7 2, (Accepted/In press) : : Journal of Applied Phycology. p. 1-8 8 p.

研究成果: Article

Ryukyu Archipelago
coral reefs
coral reef
Japan
filter

An estrogen antagonist, cyclofenil, has anti-dengue-virus activity

Tohma, D., Tajima, S., Kato, F., Sato, H., Kakisaka, M., Hishiki, T., Kataoka, M., Takeyama, H., Lim, C. K., Aida, Y. & Saijo, M., 2018 1 1, (Accepted/In press) : : Archives of Virology.

研究成果: Article

Cyclofenil
Estrogen Antagonists
Dengue Virus
Selective Estrogen Receptor Modulators
Virus Replication
1 引用 (Scopus)

A novel system for constructing a recombinant highly-attenuated Vaccinia virus strain (LC16m8) expressing foreign genes and its application for the generation of LC16m8-based vaccines against herpes simplex virus 2

Omura, N., Yoshikawa, T., Fujii, H., Shibamura, M., Inagaki, T., Kato, H., Egawa, K., Harada, S., Yamada, S., Takeyama, H. & Saijo, M., 2018 1 1, : : Japanese Journal of Infectious Diseases. 71, 3, p. 229-233 5 p.

研究成果: Article

Human Herpesvirus 2
Vaccinia virus
Glycoproteins
Vaccines
Genes
2 引用 (Scopus)

Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response

Kashima, Y., Suzuki, A., Liu, Y., Hosokawa, M., Matsunaga, H., Shirai, M., Arikawa, K., Sugano, S., Kohno, T., Takeyama, H., Tsuchihara, K. & Suzuki, Y., 2018 12 1, : : Scientific Reports. 8, 1, 3482.

研究成果: Article

Transcriptome
RNA
Aurora Kinases
Population
Genes
1 引用 (Scopus)

Effects of short-term endurance exercise on gut microbiota in elderly men

Taniguchi, H., Tanisawa, K., Sun, X., Kubo, T., Hoshino, Y., Hosokawa, M., Takeyama, H. & Higuchi, M., 2018 12 1, : : Physiological Reports. 6, 23, e13935.

研究成果: Article

Exercise
Blood Pressure
Phenotype
Metagenomics
Clostridium difficile
10 引用 (Scopus)

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

Chung, J., Wang, X., Maruyama, T., Ma, Y., Zhang, X., Mez, J., Sherva, R., Takeyama, H., Lunetta, K. L., Farrer, L. A. & Jun, G. R., 2018 1 1, (Accepted/In press) : : Alzheimer's and Dementia.

研究成果: Article

Endophenotypes
Genome-Wide Association Study
Alzheimer Disease
Single Nucleotide Polymorphism
Repression (Psychology)
1 引用 (Scopus)

Introduction of human Flt3-L and GM-CSF into humanized mice enhances the reconstitution and maturation of myeloid dendritic cells and the development of Foxp3+CD4+ T cells

Iwabuchi, R., Ikeno, S., Kobayashi-Ishihara, M., Takeyama, H., Ato, M., Tsunetsugu-Yokota, Y. & Terahara, K., 2018 5 28, : : Frontiers in Immunology. 9, MAY, 1042.

研究成果: Article

Myeloid Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Protein-Tyrosine Kinases
Dendritic Cells
Ligands
2 引用 (Scopus)

Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination

Ogawa, M., Matsuda, R., Takada, N., Tomokiyo, M., Yamamoto, S., Shizukusihi, S., Yamaji, T., Yoshikawa, Y., Yoshida, M., Tanida, I., Koike, M., Murai, M., Morita, H., Takeyama, H., Ryo, A., Guan, J. L., Yamamoto, M., Inoue, J. I., Yanagawa, T., Fukuda, M. および2人, Kawabe, H. & Ohnishi, M., 2018 8 1, : : Cellular Microbiology. 20, 8, e12846.

研究成果: Article

Ubiquitination
Autophagy
Streptococcus pneumoniae
Pneumonia
Polyubiquitin
5 引用 (Scopus)
Genome
Workflow
Microfluidics
Genetic Heterogeneity
Genomics
2 引用 (Scopus)

Protection of Coral Larvae from Thermally Induced Oxidative Stress by Redox Nanoparticles

Motone, K., Takagi, T., Aburaya, S., Aoki, W., Miura, N., Minakuchi, H., Takeyama, H., Nagasaki, Y., Shinzato, C. & Ueda, M., 2018 4 28, (Accepted/In press) : : Marine Biotechnology. p. 1-7 7 p.

研究成果: Article

Anthozoa
nanoparticles
Nanoparticles
Oxidation-Reduction
Larva
11 引用 (Scopus)

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts

Mori, T., Cahn, J. K. B., Wilson, M. C., Meoded, R. A., Wiebach, V., Martinez, A. F. C., Helfrich, E. J. N., Albersmeier, A., Wibberg, D., Dätwyler, S., Keren, R., Lavy, A., Rückert, C., Ilan, M., Kalinowski, J., Matsunaga, S., Takeyama, H. & Piel, J., 2018 2 20, : : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. 1718-1723 6 p.

研究成果: Article

Porifera
Genomics
Theonella
Polyketides
Israel
Tea
Psychological Stress
Cross-Over Studies
Capsules
Placebos
2017
12 引用 (Scopus)

A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

Wada, Y., Nithichanon, A., Nobusawa, E., Moise, L., Martin, W. D., Yamamoto, N., Terahara, K., Hagiwara, H., Odagiri, T., Tashiro, M., Lertmemongkolchai, G., Takeyama, H., Groot, A. S. D., Ato, M. & Takahashi, Y., 2017 12 1, : : Scientific Reports. 7, 1, 1283.

研究成果: Article

T-Lymphocyte Epitopes
Amino Acids
Influenza Vaccines
Epitopes
Vaccines

Analysis of environmental bacteria at single-cell level

Hosokawa, M., Nishikawa, Y., Kogawa, M. & Takeyama, H., 2017 7 26, TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems. Institute of Electrical and Electronics Engineers Inc., p. 634-637 4 p. 7994129

研究成果: Conference contribution

sequencing
bacteria
genome
Bacteria
Genes
9 引用 (Scopus)

Antimicrobial peptides extend lifespan in Drosophila

Loch, G., Zinke, I., Mori, T., Carrera, P., Schroer, J., Takeyama, H. & Hoch, M., 2017 5 1, : : PLoS One. 12, 5, e0176689.

研究成果: Article

antimicrobial peptides
Drosophila
Peptides
Pathogens
Animals
5 引用 (Scopus)

Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence

Omura, N., Fujii, H., Yoshikawa, T., Yamada, S., Harada, S., Inagaki, T., Shibamura, M., Takeyama, H. & Saijo, M., 2017 3 21, : : Virology Journal. 14, 1, 59.

研究成果: Article

Acyclovir
Thymidine Kinase
Human Herpesvirus 1
Virulence
Clone Cells
4 引用 (Scopus)

Complete genome sequence of Photobacterium damselae subsp. piscicida strain OT-51443 isolated from yellowtail (Seriola quinqueradiata) in Japan

Aoki, T., Teru, Y., Morimoto, N., Kono, T., Sakai, M., Takano, T., Hawke, J. P., Fukuda, Y., Takeyama, H. & Hikima, J. I., 2017, : : Genome Announcements. 5, 21, e00404-17.

研究成果: Article

Photobacterium
Japan
Genome
Aquaculture
Plasmids
1 引用 (Scopus)

Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA

Yoda, T., Tanabe, M., Tsuji, T., Yoda, T., Ishino, S., Shirai, T., Ishino, Y., Takeyama, H. & Nishida, H., 2017 3 16, : : Scientific Reports. 7, 44582.

研究成果: Article

Archaeal DNA
Exonucleases
Proliferating Cell Nuclear Antigen
DNA-Directed DNA Polymerase
DNA
1 引用 (Scopus)

Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I: C) influenza vaccine

Moriyama, M., Takeyama, H., Hasegawa, H. & Ichinohe, T., 2017, (Accepted/In press) : : Vaccine.

研究成果: Article

polyinosinic-polycytidylic acid
cytotoxic T-lymphocytes
Influenza Vaccines
Cytotoxic T-Lymphocytes
Orthomyxoviridae
22 引用 (Scopus)
Microfluidics
Genome
Soil
1 引用 (Scopus)

On-site Direct Detection of Astaxanthin from Salmon Fillet Using Raman Spectroscopy

Hikima, J. I., Ando, M., Hamaguchi, H. O., Sakai, M., Maita, M., Yazawa, K., Takeyama, H. & Aoki, T., 2017 4 1, : : Marine Biotechnology. 19, 2, p. 157-163 7 p.

研究成果: Article

Raman spectroscopy
astaxanthin
Raman Spectrum Analysis
Salmon
fillets
2 引用 (Scopus)
Quality Control
Quality control
Genome
Genes
Chemical analysis
1 引用 (Scopus)
Dissection
Gene Expression
Genome
Biological Science Disciplines
Transcriptome
7 引用 (Scopus)

Transcriptome analysis of immune response against Vibrio harveyi infection in orange-spotted grouper (Epinephelus coioides)

Maekawa, S., Byadgi, O., Chen, Y. C., Aoki, T., Takeyama, H., Yoshida, T., Hikima, J. I., Sakai, M., Wang, P. C. & Chen, S. C., 2017 11 1, : : Fish and Shellfish Immunology. 70, p. 628-637 10 p.

研究成果: Article

Epinephelus coioides
Vibrio harveyi
immune response
transcriptomics
Genes

Whole-genome sequence of Photobacterium damselae subsp. piscicida strain 91-197, isolated from hybrid striped bass (Morone sp.) in the United States

Teru, Y., Hikima, J. I., Kono, T., Sakai, M., Takano, T., Hawke, J. P., Takeyama, H. & Aoki, T., 2017 7 1, : : Genome Announcements. 5, 29, e00600-17.

研究成果: Article

Photobacterium
Bass
Pasteurella Infections
Genome
Aquaculture
2016
21 引用 (Scopus)

Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor

Brandstätter, O., Schanz, O., Vorac, J., König, J., Mori, T., Maruyama, T., Korkowski, M., Haarmann-Stemmann, T., Von Smolinski, D., Schultze, J. L., Abel, J., Esser, C., Takeyama, H., Weighardt, H. & Förster, I., 2016 5 17, : : Scientific Reports. 6, 26091.

研究成果: Article

Aryl Hydrocarbon Receptors
Inflammation
Xenobiotics
Interleukin-1
Endotoxins
3 引用 (Scopus)

Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicits neutralizing antibodies against JEV and hepatitis C virus

Saga, R., Fujimoto, A., Watanabe, N., Matsuda, M., Hasegawa, M., Watashi, K., Aizaki, H., Nakamura, N., Tajima, S., Takasaki, T., Konishi, E., Kato, T., Kohara, M., Takeyama, H., Wakita, T. & Suzuki, R., 2016 6 27, : : Scientific Reports. 6, 28688.

研究成果: Article

Japanese Encephalitis Virus
Neutralizing Antibodies
Hepacivirus
Vaccines
Epitopes
6 引用 (Scopus)

Characterization of a novel gene involved in cadmium accumulation screened from sponge-associated bacterial metagenome

Mori, T., Iwamoto, K., Wakaoji, S., Araie, H., Kohara, Y., Okamura, Y., Shiraiwa, Y. & Takeyama, H., 2016 2 1, : : Gene. 576, 2, p. 618-625 8 p.

研究成果: Article

Metagenome
Porifera
Cadmium
Genes
Open Reading Frames
1 引用 (Scopus)

Draft genome sequence of the fish pathogen Mycobacterium pseudoshottsii strain JCM15466, a species closely related to M. marinum

Hikima, J. I., Sakai, M., Aoki, T., Takeyama, H., Hawke, J., Mori, K., Tashiro, K. & Kuhara, S., 2016, : : Genome Announcements. 4, 1, e01630-15.

研究成果: Article

Bass
Mycobacterium
Fishes
Genome

Droplet microfluidics for precise and high throughput whole genome amplification toward single-cell genome sequencing

Hosokawa, M., Nishikawa, Y., Kogawa, M. & Takeyama, H., 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 178-179 2 p.

研究成果: Conference contribution

Microfluidics
Amplification
Genes
Throughput
DNA
4 引用 (Scopus)

Falsirhodobacter sp. alg1 Harbors Single Homologs of Endo and Exo-Type Alginate Lyases Efficient for Alginate Depolymerization

Mori, T., Takahashi, M., Tanaka, R., Miyake, H., Shibata, T., Chow, S., Kuroda, K., Ueda, M. & Takeyama, H., 2016 5 1, : : PLoS One. 11, 5, e0155537.

研究成果: Article

Depolymerization
depolymerization
alginates
Ports and harbors
Bacteria
9 引用 (Scopus)

Homeostatically maintained resting naive CD4+ T cells resist latent HIV reactivation

Tsunetsugu-Yokota, Y., Kobayahi-Ishihara, M., Wada, Y., Terahara, K., Takeyama, H., Kawana-Tachikawa, A., Tokunaga, K., Yamagishi, M., Martinez, J. P. & Meyerhans, A., 2016, : : Frontiers in Microbiology. 7, DEC, 1944.

研究成果: Article

HIV
T-Lymphocytes
T-Cell Antigen Receptor
HIV-1
Proviruses
7 引用 (Scopus)

The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine

Saito, S., Ainai, A., Suzuki, T., Harada, N., Ami, Y., Yuki, Y., Takeyama, H., Kiyono, H., Tsukada, H. & Hasegawa, H., 2016 2 24, : : Vaccine. 34, 9, p. 1201-1207 7 p.

研究成果: Article

Influenza Vaccines
Excipients
Nose
influenza
Antibody Formation
29 引用 (Scopus)

The RNA- and TRIM25-binding domains of influenza virus NS1 protein are essential for suppression of NLRP3 inflammasomemediated interleukin-1β secretion

Moriyama, M., Chen, I. Y., Kawaguchi, A., Koshiba, T., Nagata, K., Takeyama, H., Hasegawa, H. & Ichinohe, T., 2016 4 1, : : Journal of Virology. 90, 8, p. 4105-4114 10 p.

研究成果: Article

interleukin-1
Orthomyxoviridae
Interleukin-1
secretion
RNA
2015
5 引用 (Scopus)

Analysis of bacterial xylose isomerase gene diversity using gene-targeted metagenomics

Nurdiani, D., Ito, M., Maruyama, T., Terahara, T., Mori, T., Ugawa, S. & Takeyama, H., 2015 8 1, : : Journal of Bioscience and Bioengineering. 120, 2, p. 174-180 7 p.

研究成果: Article

xylose isomerase
Metagenomics
Xylose
Soil
Genes
43 引用 (Scopus)

Droplet-based microfluidics for high-throughput screening of a metagenomic library for isolation of microbial enzymes

Hosokawa, M., Hoshino, Y., Nishikawa, Y., Hirose, T., Yoon, D., Mori, T., Sekiguchi, T., Shoji, S. & Takeyama, H., 2015 5 5, : : Biosensors and Bioelectronics. 67, p. 379-385 7 p.

研究成果: Article

Metagenomics
Microfluidics
Screening
Enzymes
Throughput

Marine metagenome and supporting technology

Mori, T. & Takeyama, H., 2015 1 1, Springer Handbook of Marine Biotechnology. Springer Berlin Heidelberg, p. 497-508 12 p.

研究成果: Chapter

Metagenome
Metagenomics
Technology
genetic resource
Ecosystems
48 引用 (Scopus)

Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

Ueoka, R., Uria, A. R., Reiter, S., Mori, T., Karbaum, P., Peters, E. E., Helfrich, E. J. N., Morinaka, B. I., Gugger, M., Takeyama, H., Matsunaga, S. & Piel, J., 2015 9 20, : : Nature Chemical Biology. 11, 9, p. 705-712 8 p.

研究成果: Article

Polyketides
Macrolides
Porifera
Theonella
Actins
21 引用 (Scopus)

Monodisperse picoliter droplets for low-bias and contamination-free reactions in single-cell whole genome amplification

Nishikawa, Y., Hosokawa, M., Maruyama, T., Yamagishi, K., Mori, T. & Takeyama, H., 2015 9 21, : : PLoS One. 10, 9, e0138733.

研究成果: Article

droplets
Amplification
Contamination
Genes
Genome
54 引用 (Scopus)

Pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimp

Lai, H. C., Ng, T. H., Ando, M., Lee, C. T., Chen, I. T., Chuang, J. C., Mavichak, R., Chang, S. H., Yeh, M. D., Chiang, Y. A., Takeyama, H., Hamaguchi, H. O., Lo, C. F., Aoki, T. & Wang, H. C., 2015 12 1, : : Fish and Shellfish Immunology. 47, 2, p. 1006-1014 9 p.

研究成果: Article

necrosis
shrimp
pathogenesis
toxin
toxins