• 630 引用
  • 14 h指数
1993 …2019

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

2019

Establishment of mesophilic-like catalytic properties in a thermophilic enzyme without affecting its thermal stability

Akanuma, S., Bessho, M., Kimura, H., Furukawa, R., Yokobori, S. I. & Yamagishi, A., 2019 12 1, : : Scientific reports. 9, 1, 9346.

研究成果: Article

公開
1 引用 (Scopus)

The common ancestor of all modern life

Akanuma, S., 2019 1 1, Astrobiology: From the Origins of Life to the Search for Extraterrestrial Intelligence. Springer Singapore, p. 91-103 13 p.

研究成果: Chapter

2018

Activation of macrophages by a laccase-polymerized polyphenol is dependent on phosphorylation of Rac1

Tajima, K., Akanuma, S., Matsumoto-Akanuma, A., Yamanaka, D., Ishibashi, K. I., Adachi, Y. & Ohno, N., 2018 1 15, : : Biochemical and Biophysical Research Communications. 495, 3, p. 2209-2213 5 p.

研究成果: Article

1 引用 (Scopus)

Coarse-grained molecular dynamics simulation of sulerythrin and LARFH for producing protein nanofibers

Ozawa, T., Yamada, H., Miyakawa, T., Morikawa, R., Yagi, S., Akanuma, S., Yamagishi, A. & Takasu, M., 2018 1 18, Proceedings of the 2018 8th International Conference on Bioscience, Biochemistry and Bioinformatics, ICBBB 2018. Association for Computing Machinery, p. 43-47 5 p.

研究成果: Conference contribution

Comprehensive reduction of amino acid set in a protein suggests the importance of prebiotic amino acids for stable proteins

Shibue, R., Sasamoto, T., Shimada, M., Zhang, B., Yamagishi, A. & Akanuma, S., 2018 12 1, : : Scientific Reports. 8, 1, 1227.

研究成果: Article

9 引用 (Scopus)

Creation of artificial protein–protein interactions using α-helices as interfaces

Yagi, S., Akanuma, S. & Yamagishi, A., 2018 4 1, : : Biophysical Reviews. 10, 2, p. 411-420 10 p.

研究成果: Review article

4 引用 (Scopus)
2017

Characterization of a thermostable mutant of Agaricus brasiliensis laccase created by phylogeny-based design

Hamuro, Y., Tajima, K., Matsumoto-Akanuma, A., Sakamoto, S., Furukawa, R., Yamagishi, A., Ohno, N. & Akanuma, S., 2017, (Accepted/In press) : : Journal of Bioscience and Bioengineering.

研究成果: Article

2 引用 (Scopus)
11 引用 (Scopus)

Reconstructed ancestral enzymes suggest long-Term cooling of Earth's photic zone since the Archean

Garcia, A. K., Schopf, J. W., Yokobori, S. I., Akanuma, S. & Yamagishi, A., 2017 5 2, : : Proceedings of the National Academy of Sciences of the United States of America. 114, 18, p. 4619-4624 6 p.

研究成果: Article

15 引用 (Scopus)

Selection of a platinum-binding sequence in a loop of a four-helix bundle protein

Yagi, S., Akanuma, S., Kaji, A., Niiro, H., Akiyama, H., Uchida, T. & Yamagishi, A., 2017, (Accepted/In press) : : Journal of Bioscience and Bioengineering.

研究成果: Article

2016

Ancestral reconstruction of enzymes

Akanuma, S. & Yamagishi, A., 2016 5 17, Understanding Enzymes: Function, Design, Engineering and Analysis. Pan Stanford Publishing Pte. Ltd., p. 683-703 21 p.

研究成果: Chapter

6 引用 (Scopus)
4 引用 (Scopus)

Epistasis effects of multiple ancestral-consensus amino acid substitutions on the thermal stability of glycerol kinase from Cellulomonas sp. NT3060

Fukuda, Y., Abe, A., Tamura, T., Kishimoto, T., Sogabe, A., Akanuma, S., Yokobori, S. I., Yamagishi, A., Imada, K. & Inagaki, K., 2016 5 1, : : Journal of Bioscience and Bioengineering. 121, 5, p. 497-502 6 p.

研究成果: Article

2 引用 (Scopus)

Mutual positional preference of IPMDH proteins for binding studied by coarse-grained molecular dynamics simulation

Ishioka, T., Yamada, H., Miyakawa, T., Morikawa, R., Akanuma, S., Yamagishi, A. & Takasu, M., 2016 12 6, International Conference of Computational Methods in Sciences and Engineering 2016, ICCMSE 2016. American Institute of Physics Inc., 巻 1790. 020023

研究成果: Conference contribution

2015

Robustness of predictions of extremely thermally stable proteins in ancient organisms

Akanuma, S., Yokobori, S. I., Nakajima, Y., Bessho, M. & Yamagishi, A., 2015 11 1, : : Evolution. 69, 11, p. 2954-2962 9 p.

研究成果: Article

16 引用 (Scopus)
2014
6 引用 (Scopus)

Characterization of the low-temperature activity of Sulfolobus tokodaii glucose-1-dehydrogenase mutants

Sugii, T., Akanuma, S., Yagi, S., Yagyu, K., Shimoda, Y. & Yamagishi, A., 2014 10 1, : : Journal of Bioscience and Bioengineering. 118, 4, p. 367-371 5 p.

研究成果: Article

1 引用 (Scopus)
5 引用 (Scopus)

Evaluation of the protein interfaces that form an intermolecular four-helix bundle as studied by computer simulation

Fukuda, M., Komatsu, Y., Yamada, H., Morikawa, R., Miyakawa, T., Takasu, M., Akanuma, S. & Yamagishi, A., 2014 5 3, : : Molecular Simulation. 40, 6, p. 498-503 6 p.

研究成果: Article

3 引用 (Scopus)

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization

Abe, T., Kojima, M., Akanuma, S., Iwashita, H., Yamazaki, T., Okuyama, R., Ichikawa, K., Umemura, M., Nakano, H., Takahashi, S. & Takahashi, Y., 2014 2 14, : : Journal of Biological Chemistry. 289, 7, p. 3888-3900 13 p.

研究成果: Article

5 引用 (Scopus)

Preparation of Phi29 DNA polymerase free of amplifiable DNA using ethidium monoazide, an ultraviolet-free light-emitting diode lamp and trehalose

Takahashi, H., Yamazaki, H., Akanuma, S., Kanahara, H., Saito, T., Chimuro, T., Kobayashi, T., Ohtani, T., Yamamoto, K., Sugiyama, S. & Kobori, T., 2014 2 5, : : PloS one. 9, 2, e82624.

研究成果: Article

7 引用 (Scopus)
2013

Comparative genomics of thermophilic bacteria and archaea

Akanuma, S., Yokobori, S. I. & Yamagishi, A., 2013 1 1, Thermophilic Microbes in Environmental and Industrial Biotechnology: Biotechnology of Thermophiles. Springer Netherlands, p. 331-349 19 p.

研究成果: Chapter

5 引用 (Scopus)

Experimental evidence for the thermophilicity of ancestral life

Akanuma, S., Nakajima, Y., Yokobori, S. I., Kimura, M., Nemoto, N., Mase, T., Miyazono, K. I., Tanokura, M. & Yamagishi, A., 2013 7 2, : : Proceedings of the National Academy of Sciences of the United States of America. 110, 27, p. 11067-11072 6 p.

研究成果: Article

83 引用 (Scopus)

The simulation study of protein-protein interfaces based on the 4-helix bundle structure

Fukuda, M., Komatsu, Y., Morikawa, R., Miyakawa, T., Takasu, M., Akanuma, S. & Yamagishi, A., 2013 3 12, 4th International Symposium on Slow Dynamics in Complex Systems: Keep Going Tohoku. p. 606-609 4 p. (AIP Conference Proceedings; 巻数 1518).

研究成果: Conference contribution

2 引用 (Scopus)
2012

Constructing protein nano-fiber and estimation of the electronic state around metal ions

Komatsu, Y., Fukuda, M., Yamada, H., Kawamoto, S., Miyakawa, T., Morikawa, R., Takasu, M., Yokojima, S., Akanuma, S. & Yamagishi, A., 2012 12 15, : : International Journal of Quantum Chemistry. 112, 24, p. 3750-3755 6 p.

研究成果: Article

3 引用 (Scopus)
2011
9 引用 (Scopus)

Phylogeny-based design of a B-subunit of DNA gyrase and its ATPase domain using a small set of homologous amino acid sequences

Akanuma, S., Iwami, S., Yokoi, T., Nakamura, N., Watanabe, H., Yokobori, S. I. & Yamagishi, A., 2011 9 16, : : Journal of Molecular Biology. 412, 2, p. 212-225 14 p.

研究成果: Article

14 引用 (Scopus)
2 引用 (Scopus)

Substitutions of coenzyme-binding, nonpolar residues improve the low-temperature activity of thermophilic dehydrogenases

Hayashi, S., Akanuma, S., Onuki, W., Tokunaga, C. & Yamagishi, A., 2011 10 11, : : Biochemistry. 50, 40, p. 8583-8593 11 p.

研究成果: Article

8 引用 (Scopus)
2010

Mimicking the evolution of a thermally stable monomeric four-helix bundle by fusion of four identical single-helix peptides

Akanuma, S., Matsuba, T., Ueno, E., Umeda, N. & Yamagishi, A., 2010 3 1, : : Journal of biochemistry. 147, 3, p. 371-379 9 p.

研究成果: Article

16 引用 (Scopus)
2009

Why are thermophilic proteins thermally stable?

Akanuma, S. & Yamagishi, A., 2009 12 1, : : Seikagaku. 81, 12, p. 1064-1071 8 p.

研究成果: Article

2008
20 引用 (Scopus)

Methods for reducing nonspecific interaction in antibody-antigen assay via atomic force microscopy

Wakayama, J., Sekiguchi, H., Akanuma, S., Ohtani, T. & Sugiyama, S., 2008 9 1, : : Analytical Biochemistry. 380, 1, p. 51-58 8 p.

研究成果: Article

27 引用 (Scopus)
4 引用 (Scopus)
2005

A detailed unfolding pathway of a (β/α)8-barrel protein as studied by molecular dynamics simulations

Akanuma, S., Miyagawa, H., Kitamura, K. & Yamagishi, A., 2005 2 15, : : Proteins: Structure, Function and Genetics. 58, 3, p. 538-546 9 p.

研究成果: Article

8 引用 (Scopus)
13 引用 (Scopus)
2002
66 引用 (Scopus)
2001
8 引用 (Scopus)
2000
10 引用 (Scopus)
1999
45 引用 (Scopus)
1998
71 引用 (Scopus)
1997

A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase

Qu, C., Akanuma, S., Moriyama, H., Tanaka, N. & Oshima, T., 1997 2 21, : : Protein Engineering. 10, 1, p. 45-52 8 p.

研究成果: Article

18 引用 (Scopus)

Effect of polar side chains at position 172 on thermal stability of 3- isopropylmalate dehydrogenase from Thermus thermophilus

Akanuma, S., Qu, C., Yamagishi, A., Tanaka, N. & Oshima, T., 1997 6 30, : : FEBS Letters. 410, 2-3, p. 141-144 4 p.

研究成果: Article

15 引用 (Scopus)
1996
公開
58 引用 (Scopus)
公開
9 引用 (Scopus)
1993

Recombination-deficient mutants of an extreme thermophile, Thermus thermophilus

Takada, T., Akanuma, S., Kotsuka, T., Tamakoshi, M., Yamagishi, A. & Oshima, T., 1993 1 1, : : Applied and Environmental Microbiology. 59, 8, p. 2737-2739 3 p.

研究成果: Comment/debate

18 引用 (Scopus)