Takashi Kato

1997

Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization

Nomura, S., Ogami, K., Kawamura, K., Tsukamoto, I., Kudo, Y., Kanakura, Y., Kitamura, Y., Miyazaki, H. & Kato, T., 1997 7月 30, In: Experimental Hematology. 25, 7, p. 565-572 8 p.

研究成果: Article › 査読

65 被引用数 (Scopus)

Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia

Ishiguro, A., Nakahata, T., Muraoka, K., Tomoyuki Tahara, T., Miyazaki, H., Kato, T., Inaba, Y. & Shimbo, T., 1997 7月, In: International Journal of Hematology. 66, 1, p. 99-102 4 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation

Hiyoyama, K., Wada, H., Shimura, M., Nakasaki, T., Katayama, N., Nishikawa, M., Shiku, H., Tahara, T. & Kato, T., 1997 1月 1, In: Blood Coagulation and Fibrinolysis. 8, 6, p. 345-349 5 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia

Horikawa, Y., Matsumura, I., Hashimoto, K., Shiraga, M., Kosugi, S., Tadokoro, S., Kato, T., Miyazaki, H., Tomiyama, Y., Kurata, Y., Matsuzawa, Y. & Kanakura, Y., 1997 11月 15, In: Blood. 90, 10, p. 4031-4038 8 p.

研究成果: Article › 査読

Open Access

168 被引用数 (Scopus)

Measurement of endogenous plasma thrombopoietin in patients with acquired aplastic anaemia by a sensitive enzyme-linked immunosorbent assay

Kojima, S., Matsuyama, T., Kodera, Y., Tahara, T. & Kato, T., 1997, In: British Journal of Haematology. 97, 3, p. 538-543 6 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8

Higuchi, T., Koike, K., Sawai, N., Mwamtemi, H. H., Takeuchi, K., Shiohara, M., Kikuchi, T., Yasui, K., Ito, S., Yamagami, O., Sasaki, Y., Okumura, N., Kato, T., Miyazaki, H., Ikeda, M., Yamada, M. & Komiyama, A., 1997, In: British Journal of Haematology. 99, 3, p. 509-516 8 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Protein kinase C and c-myc gene activation pathways in thrombopoietin signal transduction

Kunitama, M., Shimizu, R., Yamada, M., Kato, T., Miyazaki, H., Okada, K., Miura, Y. & Komatsu, N., 1997 2月 13, In: Biochemical and Biophysical Research Communications. 231, 2, p. 290-294 5 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Purification and biochemical properties of thrombopoietin

Kato, T., 1997 12月 1, In: Seikagaku. 69, 6, p. 433-438 6 p.

研究成果: Article › 査読

Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro

Tanimukai, S., Kimura, T., Sakabe, H., Ohmizono, Y., Kato, T., Miyazaki, H., Yamagishi, H. & Sonoda, Y., 1997 10月 1, In: Experimental Hematology. 25, 10, p. 1025-1033 9 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Role for C-MPL and its Ligand Thrombopoietin in Early Hematopoiesis

Katayamaa, N., Itoh, R., Kato, T., Sugawara, T., Mahmud, N., Ohish, K., Masuya, M., Aoki, M., Minami, N., Miyazaki, H. & Shiku, H., 1997 1月 1, In: Leukemia and Lymphoma. 28, 42006, p. 51-56 6 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Serum thrombopoietin levels in patients receiving high-dose chemotherapy with support of purified peripheral blood CD34+ cells

Okamoto, Y., Kawano, Y., Takaue, Y., Watanabe, T., Kato, T., Shimosaka, A. & Kuroda, Y., 1997 11月 15, In: Cancer Research. 57, 22, p. 5037-5040 4 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Thrombin cleaves recombinant human thrombopoietin: One of the proteolytic events that generates truncated forms of thrombopoietin

Kato, T., Oda, A., Inagaki, Y., Ohashi, H., Matsumoto, A., Ozaki, K., Miyakawa, Y., Watarai, H., Fuju, K., Kokubo, A., Kadoya, T., Ikeda, Y. & Miyazaki, H., 1997 4月 29, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 9, p. 4669-4674 6 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Thrombopoietin, steel factor and the ligand for flt3/flk2 interact to stimulate the proliferation of human hematopoietic progenitors in culture

Kobayashi, M., Laver, J. H., Lyman, S. D., Kato, T., Miyazaki, H. & Ogawa, M., 1997 12月, In: International Journal of Hematology. 66, 4, p. 423-434 12 p.

研究成果: Article › 査読

Open Access

17 被引用数 (Scopus)

Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21 (WAF1/Cip1) by STAT5

Matsumura, I., Ishikawa, J., Nakajima, K., Oritani, K., Tomiyama, Y., Miyagawa, J. I., Kato, T., Miyazaki, H., Matsuzawa, Y. & Kanakura, Y., 1997 5月, In: Molecular and Cellular Biology. 17, 5, p. 2933-2943 11 p.

研究成果: Article › 査読

Open Access

171 被引用数 (Scopus)

1996

Activity of the ligand for c-mpl, thrombopoietin, in early haemopoiesis

Itoh, R., Katayama, N., Kato, T., Mahmud, N., Masuya, M., Ohishi, K., Minami, N., Miyazaki, H. & Shiku, H., 1996 1月 1, In: British Journal of Haematology. 94, 2, p. 228-235 8 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

A highly sensitive and specific ellsa for measuring thrombopoietin in human serum

Tahara, T., Usuki, K., Sato, H., Ohashi, H., Monta, H., Taiimura, H., Mivazaki', H. & Kato, T., 1996, In: Experimental Hematology. 24, 9, p. 1068 1 p.

研究成果: Article › 査読

Analysis of functional domains of the human tpo receptor encoded by C-MPL

Takatoku, M., Komateu, N., Shimizu, R., Kato, T., Miyazakis, H. & Miuräï, Y., 1996 12月 1, In: Experimental Hematology. 24, 9, 1 p.

研究成果: Article › 査読

A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders

Tahara, T., Usuki, K., Sato, H., Ohashi, H., Morita, H., Tsumura, H., Matsumoto, A., Miyazaki, H., Urabe, A. & Kato, T., 1996 1月 1, In: British Journal of Haematology. 93, 4, p. 783-788 6 p.

研究成果: Article › 査読

197 被引用数 (Scopus)

Circulating endogenous thrombopoietin, interleukin-3, interleukin-6 and interleukin-11 levels in patients undergoing allogeneic bone marrow transplantation

Ishida, A., Miyakawa, Y., Tanosaki, R., Wakui, M., Ueno, H., Watanabe, R., Awaya, N., Tahara, T., Kato, T., Miyazaki, H., Oda, A., Kizaki, M., Okamoto, S. & Ikeda, Y., 1996 12月, In: International Journal of Hematology. 65, 1, p. 61-69 9 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

Kosugi, S., Kurata, Y., Tomiyama, Y., Tahara, T., Kato, T., Tadokoro, S., Shiraga, M., Honda, S., Kanakura, Y. & Matsuzawa, Y., 1996 1月 1, In: British Journal of Haematology. 93, 3, p. 704-706 3 p.

研究成果: Article › 査読

169 被引用数 (Scopus)

Coexpression of thrombopoietin and c-mpl genes in human acute myeloblastic leukemia cells

Matsumura, I., Kanakura, Y., Ikeda, H., Ishikawa, J., Yoshida, H., Horikawa, Y., Nishiura, T., Tahara, T., Kato, T., Miyazaki, H. & Matsuzawa, Y., 1996 1月, In: Leukemia. 10, 1, p. 91-94 4 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Cyclic change of cytokines in a patient with cyclic thrombocytopenia

Kimura, F., Nakamura, Y., Sato, K., Wakimoto, N., Kato, T., Tahara, T., Yamada, M., Nagata, N. & Motoyoshi, K., 1996, In: British Journal of Haematology. 94, 1, p. 171-174 4 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia

Akahori, H., Shibuya, K., Obuchi, M., Nishizawa, Y., Tsuji, A., Kabaya, K., Kusaka, M., Ohashi, H., Tsumura, H., Kato, T. & Miyazaki, H., 1996 1月 1, In: British Journal of Haematology. 94, 4, p. 722-728 7 p.

研究成果: Article › 査読

50 被引用数 (Scopus)

Effects of pegylated recombinant human megakaryocyte growth and development factor on thrombocytopenia induced by a new myelosuppressive chemotherapy regimen in mice

Akahori, H., Shibuya, K., Ozai, M., Ida, M., Kabaya, K., Kato, T. & Miyazaki, H., 1996 11月, In: STEM CELLS. 14, 6, p. 678-689 12 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO

Komatsu, N., Kunitama, M., Yamada, M., Hagiwara, T., Kato, T., Miyazaki, H., Eguchi, M., Yamamoto, M. & Miura, Y., 1996 6月 1, In: Blood. 87, 11, p. 4552-4560 9 p.

研究成果: Article › 査読

Open Access

87 被引用数 (Scopus)

Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation

Morita, H., Tahara, T., Matsumoto, A., Kato, T., Miyazaki, H. & Ohashi, H., 1996 10月 21, In: FEBS Letters. 395, 2-3, p. 228-234 7 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

GpIIb/IIIa⁺ subpopulation of rat megakaryocyte progenitor cells exhibits high responsiveness to human thrombopoietin

Kato, T., Horie, K., Hagiwara, T., Maeda, E., Tsumura, H., Ohashi, H. & Miyazaki, H., 1996 9月 3, In: Experimental Hematology. 24, 10, p. 1209-1214 6 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Immunocytochemical localization of prohormone convertases PC1/PC3 and PC2 in rat pancreatic islets

Tanaka, S., Kurabuchi, S., Mochida, H., Kato, T., Takahashi, S., Watanabe, T. & Nakayama, K., 1996, In: Archives of Histology and Cytology. 59, 3, p. 261-271 11 p.

研究成果: Article › 査読

Open Access

48 被引用数 (Scopus)

Improvement of thrombocytopenia following bone marrow transplantation by pegylated recombinant human megakaryocyte growth and development factor in mice

Kabaya, K., Shibuya, K., Torii, Y., Nitta, Y., Ida, M., Akahori, H., Kato, T., Kusaka, M. & Miyazaki, H., 1996 12月 1, In: Bone Marrow Transplantation. 18, 6, p. 1035-1041 7 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

In vivo effects of pegylated recombinant human megakaryocyte growth and development factor on hematopoiesis in normal mice

Kabaya, K., Akahori, H., Shibuya, K., Nitta, Y., Ida, M., Kusaka, M., Kato, T. & Miyazaki, H., 1996 11月, In: STEM CELLS. 14, 6, p. 651-660 10 p.

研究成果: Article › 査読

36 被引用数 (Scopus)

Plasma thrombopoietin concentrations in patients with acquired aplastic anemia

Kojima, S., Matsuyama, T., Kodera, Y., Tahara, T. & Kato, T., 1996, In: Experimental Hematology. 24, 9, p. 1063 1 p.

研究成果: Article › 査読

Protein characteristics of thrombopoietin

Kato, T., 1996, In: STEM CELLS. 14, SUPPL. 1, p. 139-147 9 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura

Ichikawa, N., Ishida, F., Shimodaira, S., Tahara, T., Kato, T. & Kitano, K., 1996, In: Thrombosis and Haemostasis. 76, 2, p. 156-160 5 p.

研究成果: Article › 査読

92 被引用数 (Scopus)

Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis

Shimodaira, S., Ishida, F., Ichikawa, N., Tahara, T., Kato, T., Kodaira, H., Ito, T., Tanaka, E., Sodeyama, T., Kiyosawa, K. & Kitano, K., 1996 10月, In: Thrombosis and Haemostasis. 76, 4, p. 545-548 4 p.

研究成果: Article › 査読

56 被引用数 (Scopus)

Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura

Mukai, H. Y., Kojima, H., Todokoro, K., Tahara, T., Kato, T., Hasegawa, Y., Kobayashi, T., Ninomiya, H., Nagasawa, T. & Abe, T., 1996 11月, In: Thrombosis and Haemostasis. 76, 5, p. 675-678 4 p.

研究成果: Article › 査読

63 被引用数 (Scopus)

Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic disorders

Kunishima, S., Tahara, T., Kato, T., Kobayashi, S., Saito, H. & Naoe, T., 1996, In: European Journal of Haematology. 57, 1, p. 68-71 4 p.

研究成果: Article › 査読

36 被引用数 (Scopus)

Serum thrombopoietin level in various hematological diseases

Usuki, K., Tahara, T., Iki, S., Endo, M., Osawa, M., Kitazume, K., Kato, T., Miyazaki, H. & Urabe, A., 1996 9月, In: STEM CELLS. 14, 5, p. 558-565 8 p.

研究成果: Article › 査読

54 被引用数 (Scopus)

Serum thrombopoietin level in various hematological diseases

Urabe, A., Usuki, K., Iki, S., Endo, M., Tahara, T., Kato, T. & Mivazaki, H., 1996 12月 1, In: Experimental Hematology. 24, 9, 1 p.

研究成果: Article › 査読

Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2

Ku, H., Hirayama, F., Kato, T., Miyazaki, H., Aritomi, M., Ota, Y., D'Andrea, A. D., Lyman, S. D. & Ogawa, M., 1996 12月 1, In: Blood. 88, 11, p. 4124-4131 8 p.

研究成果: Article › 査読

Open Access

32 被引用数 (Scopus)

The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells

Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Horikawa, Y., Ishikawa, J., Kitayama, H., Nishiura, T., Tomiyama, Y., Miyazaki, H. & Matsuzawa, Y., 1996 10月 15, In: Blood. 88, 8, p. 3074-3082 9 p.

研究成果: Article › 査読

Open Access

35 被引用数 (Scopus)

Thrombopoietin has a direct effect on erythroid differentiation

Yamada, M., Komatsu, N., Kirito, K., Shimizu, R., Kato, T., Mivazak, R., Abe, P. K. & Miura, Y., 1996 12月 1, In: Experimental Hematology. 24, 9, 1 p.

研究成果: Article › 査読

Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists

Oda, A., Miyakawa, Y., Druker, B. J., Ozaki, K., Yabusaki, K., Shirasawa, Y., Handa, M., Kato, T., Miyazaki, H., Shimosaka, A. & Ikeda, Y., 1996 6月 1, In: Blood. 87, 11, p. 4664-4670 7 p.

研究成果: Article › 査読

Open Access

117 被引用数 (Scopus)

Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3

Kobayashi, M., Laver, J. H., Kato, T., Miyazaki, H. & Ogawa, M., 1996 7月 15, In: Blood. 88, 2, p. 429-436 8 p.

研究成果: Article › 査読

Open Access

191 被引用数 (Scopus)

1995

A simple and quantitative liquid culture system to measure megakaryocyte growth using highly purified CSU-MK

Miyazaki, H., Horie, K., Shimada, Y., Kokubo, A., Maeda, E., Inoue, H. & Kato, T., 1995 1月 1, In: Experimental Hematology. 23, 11, p. 1224-1228 5 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin

Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Ishikawa, J., Horikawa, Y., Hashimoto, K., Moriyama, Y., Tsujimura, T., Nishiura, T., Miyazaki, H. & Matsuzawa, Y., 1995 7月 15, In: Blood. 86, 2, p. 703-709 7 p.

研究成果: Article › 査読

Open Access

88 被引用数 (Scopus)

Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy- induced thrombocytopenia

Nichol, J. L., Hokom, M. M., Hornkohl, A., Sheridan, W. P., Ohashi, H., Kato, T., Yue Sheng Li, S. L., Bartley, T. D., Choi, E., Bogenberger, J., Skrine, J. D., Knudten, A., Chen, J., Trail, G., Sleeman, L., Cole, S., Grampp, G. & Hunt, P., 1995, In: Journal of Clinical Investigation. 95, 6, p. 2973-2978 6 p.

研究成果: Article › 査読

Open Access

193 被引用数 (Scopus)

Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines

Shimada, Y., Kato, T., Ogami, K., Horie, K., Kokubo, A., Kudo, Y., Maeda, E., Sohma, Y., Akahori, H., Kawamura, K. & Miyazaki, H., 1995 12月 1, In: Experimental Hematology. 23, 13, p. 1388-1396 9 p.

研究成果: Article › 査読

86 被引用数 (Scopus)

Purification and characterization of thrombopoietin

Kato, T., Ogami, K., Shimada, Y., Iwamatsu, A., Sohma, Y., Akahori, H., Horie, K., Kokubo, A., Kudo, Y., Maeda, E., Kobayashi, K., Ohashi, H., Ozawa, T., Inoue, H., Kawamura, K. & Miyazaki, H., 1995 7月, In: Journal of biochemistry. 118, 1, p. 229-236 8 p.

研究成果: Article › 査読

248 被引用数 (Scopus)

Recombinant human megakaryocyte growth and development factor (rhumgdf), a ligand for c‐mpl, produces functional human platelets in vitro

Choi, E. S., Hokom, M., Bartley, T., Li, YS. S., Nichol, J. L., Skrine, J., Knudten, A., Chen, J., Hornkohl, A., Grampp, G., Sleeman, L., Cole, S., Trail, G., Hunt, P., Ohashi, H. & Kato, T., 1995, In: STEM CELLS. 13, 3, p. 317-322 6 p.

研究成果: Article › 査読

91 被引用数 (Scopus)

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

Kobayashi, M., Laver, J. H., Kato, T., Miyazaki, H. & Ogawa, M., 1995 10月 1, In: Blood. 86, 7, p. 2494-2499 6 p.

研究成果: Article › 査読

Open Access

159 被引用数 (Scopus)

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