Youichi Nakao

2022

Coronarin D, a Metabolite from the Wild Turmeric, Curcuma aromatica, Promotes the Differentiation of Neural Stem Cells into Astrocytes

Otsuka, S., Kawamura, M., Fujino, S., Nakamura, F., Arai, D., Fusetani, N. & Nakao, Y., 2022 3月 16, In: Journal of Agricultural and Food Chemistry. 70, 10, p. 3300-3309 10 p.

研究成果: Article › 査読

Open Access

Preparation and Application of a Chemical Probe for Identifying the Targets of the Marine Cyclic Peptide Kapakahine A

Kamihira, R. & Nakao, Y., 2022 2月 1, In: Molecules. 27, 3, 1072.

研究成果: Article › 査読

Open Access

2021

A soft spot for chemistry–current taxonomic and evolutionary implications of sponge secondary metabolite distribution

Galitz, A., Nakao, Y., Schupp, P. J., Wörheide, G. & Erpenbeck, D., 2021 8月, In: Marine Drugs. 19, 8, 448.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy

Vong, K., Tahara, T., Urano, S., Nasibullin, I., Tsubokura, K., Nakao, Y., Kurbangalieva, A., Onoe, H., Watanabe, Y. & Tanaka, K., 2021 4月 21, In: Science Advances. 7, 17, eabg4038.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Efficient biallelic knock-in in mouse embryonic stem cells by in vivo-linearization of donor and transient inhibition of DNA polymerase θ/DNA-PK

Arai, D. & Nakao, Y., 2021 12月, In: Scientific reports. 11, 1, 18132.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Epigenetic effects of insecticides on early differentiation of mouse embryonic stem cells

Wang, W., Ito, T., Otsuka, S., Nansai, H., Abe, K., Nakao, Y., Ohgane, J., Yoneda, M. & Sone, H., 2021 9月, In: Toxicology in Vitro. 75, 105174.

研究成果: Article › 査読

2 被引用数 (Scopus)

In vivometal-catalyzed SeCT therapy by a proapoptotic peptide

Ahmadi, P., Muguruma, K., Chang, T. C., Tamura, S., Tsubokura, K., Egawa, Y., Suzuki, T., Dohmae, N., Nakao, Y. & Tanaka, K., 2021 10月 7, In: Chemical Science. 12, 37, p. 12266-12273 8 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Small-Scale Preparation of Fluorescently Labeled Chemical Probes from Marine Cyclic Peptides, Kapakahines A and F

Kamihira, R. & Nakao, Y., 2021 2月, In: Marine Drugs. 19, 2, 76.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

THE EFFICACY OF MARINE NATURAL PRODUCTS AGAINST PLASMODIUM FALCIPARUM

Goto, Y., Kamihira, R., Nakao, Y., Nonaka, M., Takano, R., Xuan, X. & Kato, K., 2021 3月 1, In: Journal of Parasitology. 107, 2, p. 284-288 5 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Triggering Growth via Growth Initiation Factors in Nature: A Putative Mechanism for in situ Cultivation of Previously Uncultivated Microorganisms

Jung, D., Machida, K., Nakao, Y., Kindaichi, T., Ohashi, A. & Aoi, Y., 2021 5月 4, In: Frontiers in Microbiology. 12, 537194.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

2020

Combinatorial effects of soluble, insoluble, and organic extracts from jerusalem artichokes on gut microbiota in mice

Sasaki, H., Lyu, Y., Nakayama, Y., Nakamura, F., Watanabe, A., Miyakawa, H., Nakao, Y. & Shibata, S., 2020 6月, In: Microorganisms. 8, 6, p. 1-19 19 p., 954.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Efficient synthesis ofmarine alkaloid ageladine A and its structural modification for exploring new biological activity

Iwata, T., Fukase, K., Nakao, Y. & Tanaka, K., 2020, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 78, 1, p. 51-59 9 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Histone modification dynamics as revealed by multicolor immunofluorescence-based single-cell analysis

Hayashi-Takanaka, Y., Kina, Y., Nakamura, F., Becking, L. E., Nakao, Y., Nagase, T., Nozaki, N. & Kimura, H., 2020 7月, In: Journal of Cell Science. 133, 14, jcs243444.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Zhao, M., Xiao, Y., Otsuka, S., Nakao, Y., Guo, Y. & Ye, T., 2020 5月 13, In: Frontiers in Chemistry. 8, 410.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

2019

Effect of mycalolides isolated from a marine sponge Mycale aff. nullarosette on actin in living cells

Hayashi-Takanaka, Y., Kina, Y., Nakamura, F., Yamazaki, S., Harata, M., Soest, R. W. M. V., Kimura, H. & Nakao, Y., 2019 12月 1, In: Scientific reports. 9, 1, 7540.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Efficient route to RIKEN click probes for glycoconjugation

Nakamura, K., Tsubokura, K., Kurbangalieva, A., Nakao, Y., Murase, T., Shimoda, T. & Tanaka, K., 2019 2月 12, In: Journal of Carbohydrate Chemistry. 38, 2, p. 127-138 12 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2018

Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Nakamura, F., Kudo, N., Tomachi, Y., Nakata, A., Takemoto, M., Ito, A., Tabei, H., Arai, D., De Voogd, N., Yoshida, M., Nakao, Y. & Fusetani, N., 2018 2月 1, In: Journal of Antibiotics. 71, 2, p. 273-278 6 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Nakamura, F., Maejima, H., Kawamura, M., Arai, D., Okino, T., Zhao, M., Ye, T., Lee, J., Chang, Y. T., Fusetani, N. & Nakao, Y., 2018 7月 1, In: Bioorganic and Medicinal Chemistry Letters. 28, 12, p. 2206-2209 4 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Sameuramide A, a new cyclic depsipeptide isolated from an ascidian of the family Didemnidae

Machida, K., Arai, D., Katsumata, R., Otsuka, S., Yamashita, J. K., Ye, T., Tang, S., Fusetani, N. & Nakao, Y., 2018 7月 30, In: Bioorganic and Medicinal Chemistry. 26, 13, p. 3852-3857 6 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

2017

A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B

Takase, S., Kurokawa, R., Arai, D., Kanto, K. K., Okino, T., Nakao, Y., Kushiro, T., Yoshida, M. & Matsumoto, K., 2017 12月 1, In: Scientific reports. 7, 1, 2002.

研究成果: Article › 査読

14 被引用数 (Scopus)

Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

Vong, K. K. H., Tsubokura, K., Nakao, Y., Tanei, T., Noguchi, S., Kitazume, S., Taniguchi, N. & Tanaka, K., 2017, In: Chemical Communications. 53, 60, p. 8403-8406 4 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Dolabellol A, a new halogenated diterpene isolated from the opisthobranch dolabella auricularia

Machida, K., Matsumoto, T., Fusetani, N. & Nakao, Y., 2017, In: Chemistry Letters. 46, 11, p. 1676-1678 3 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Identification of zinc finger transcription factor EGR2 as a novel acetylated protein

Noritsugu, K., Ito, A., Nakao, Y. & Yoshida, M., 2017 8月 5, In: Biochemical and Biophysical Research Communications. 489, 4, p. 455-459 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

In Vivo Gold Complex Catalysis within Live Mice

Tsubokura, K., Vong, K. K. H., Pradipta, A. R., Ogura, A., Urano, S., Tahara, T., Nozaki, S., Onoe, H., Nakao, Y., Sibgatullina, R., Kurbangalieva, A., Watanabe, Y. & Tanaka, K., 2017 3月 20, In: Angewandte Chemie - International Edition. 56, 13, p. 3579-3584 6 p.

研究成果: Article › 査読

91 被引用数 (Scopus)

RETRACTED: In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

Yamamizu, K., Iwasaki, M., Takakubo, H., Sakamoto, T., Ikuno, T., Miyoshi, M., Kondo, T., Nakao, Y., Nakagawa, M., Inoue, H. & Yamashita, J. K., 2017 3月 14, In: Stem Cell Reports. 8, 3, p. 634-647 14 p.

研究成果: Article › 査読

Open Access

39 被引用数 (Scopus)

Trypanocidal activity, cytotoxicity and histone modifications induced by malformin A₁ isolated from the marine-derived fungus Aspergillus tubingensis IFM 63452

Notarte, K. I., Nakao, Y., Yaguchi, T., Bungihan, M., Suganuma, K. & dela Cruz, T. E., 2017, In: Mycosphere. 8, 1, 10.

研究成果: Article › 査読

12 被引用数 (Scopus)

2016

A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member

Nakaoka, S., Sasaki, K., Ito, A., Nakao, Y. & Yoshida, M., 2016 3月 18, In: ACS Chemical Biology. 11, 3, p. 729-733 5 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation

Iwata, T., Otsuka, S., Tsubokura, K., Kurbangalieva, A., Arai, D., Fukase, K., Nakao, Y. & Tanaka, K., 2016 10月 4, In: Chemistry - A European Journal. 22, 41, p. 14707-14716 10 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Piceatannol is superior to resveratrol in promoting neural stem cell differentiation into astrocytes

Arai, D., Kataoka, R., Otsuka, S., Kawamura, M., Maruki-Uchida, H., Sai, M., Ito, T. & Nakao, Y., 2016 10月, In: Food and Function. 7, 10, p. 4432-4441 10 p.

研究成果: Article › 査読

Open Access

25 被引用数 (Scopus)

Synthesis and antileishmanial activity of the core structure of cristaxenicin A

Fumiyama, H., Sadayuki, T., Osada, Y., Goto, Y., Nakao, Y. & Hosokawa, S., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 17, p. 4355-4357 3 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2015

An epigenetic regulatory element of the Nodal gene in the mouse and human genomes

Arai, D., Hayakawa, K., Ohgane, J., Hirosawa, M., Nakao, Y., Tanaka, S. & Shiota, K., 2015 5月 1, In: Mechanisms of Development. 136, p. 143-154 12 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

2014

Assay methods for small ubiquitin-like modifier (SUMO)-SUMO-interacting motif (SIM) interactions in vivo and in vitro using a split-luciferase complementation system

Hirohama, M., Voet, A. R. D., Ozawa, T., Saitoh, H., Nakao, Y., Zhang, K. Y. J., Ito, A. & Yoshida, M., 2014 3月 1, In: Analytical Biochemistry. 448, 1, p. 92-94 3 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Cinanthrenol A, an estrogenic steroid containing phenanthrene nucleus, from a marine sponge cinachyrella sp.

Machida, K., Abe, T., Arai, D., Okamoto, M., Shimizu, I., De Voogd, N. J., Fusetani, N. & Nakao, Y., 2014 3月 21, In: Organic Letters. 16, 6, p. 1539-1541 3 p.

研究成果: Article › 査読

17 被引用数 (Scopus)

Direct guanylation of amino groups by cyanamide in water: Catalytic generation and activation of unsubstituted carbodiimide by scandium(iii) triflate

Tsubokura, K., Iwata, T., Taichi, M., Kurbangalieva, A., Fukase, K., Nakao, Y. & Tanaka, K., 2014 6月, In: Synlett. 25, 9, p. 1302-1306 5 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Takemoto, M., Kawamura, Y., Hirohama, M., Yamaguchi, Y., Handa, H., Saitoh, H., Nakao, Y., Kawada, M., Khalid, K., Koshino, H., Kimura, K. I., Ito, A. & Yoshida, M., 2014 4月, In: Journal of Antibiotics. 67, 4, p. 335-338 4 p.

研究成果: Article › 査読

32 被引用数 (Scopus)

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges

Sepe, V., D'Amore, C., Ummarino, R., Renga, B., D'Auria, M. V., Novellino, E., Sinisi, A., Taglialatela-Scafati, O., Nakao, Y., Limongelli, V., Zampella, A. & Fiorucci, S., 2014 2月 12, In: European Journal of Medicinal Chemistry. 73, p. 126-134 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

2013

Spectomycin B1 as a novel sumoylation inhibitor that directly binds to SUMO E2

Hirohama, M., Kumar, A., Fukuda, I., Matsuoka, S., Igarashi, Y., Saitoh, H., Takagi, M., Shin-Ya, K., Honda, K., Kondoh, Y., Saito, T., Nakao, Y., Osada, H., Zhang, K. Y. J., Yoshida, M. & Ito, A., 2013 12月 20, In: ACS Chemical Biology. 8, 12, p. 2635-2642 8 p.

研究成果: Article › 査読

75 被引用数 (Scopus)

Stereochemical analysis and cytotoxicity of kulokekahilide-2 and its analogues

Umehara, M., Negishi, T., Maehara, Y., Nakao, Y. & Kimura, J., 2013 4月 8, In: Tetrahedron. 69, 14, p. 3045-3053 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2012

Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Ishigami, S. T., Goto, Y., Inoue, N., Kawazu, S. I., Matsumoto, Y., Imahara, Y., Tarumi, M., Nakai, H., Fusetani, N. & Nakao, Y., 2012 12月 7, In: Journal of Organic Chemistry. 77, 23, p. 10962-10966 5 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei

Sepe, V., Ummarino, R., D'Auria, M. V., Taglialatela-Scafati, O., De Marino, S., D'Amore, C., Renga, B., Chini, M. G., Bifulco, G., Nakao, Y., Fusetani, N., Fiorucci, S. & Zampella, A., 2012 11月, In: Marine Drugs. 10, 11, p. 2448-2466 19 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk

Umehara, M., Negishi, T., Tashiro, T., Nakao, Y. & Kimura, J., 2012 12月 15, In: Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7422-7425 4 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

The total synthesis and structure-activity relationships of a highly cytotoxic depsipeptide kulokekahilide-2 and its analogs

Takada, Y., Umehara, M., Katsumata, R., Nakao, Y. & Kimura, J., 2012 1月 14, In: Tetrahedron. 68, 2, p. 659-669 11 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

2011

A one-pot synthesis and biological activity of ageladine A and analogues

Shengule, S. R., Loa-Kum-Cheung, W. L., Parish, C. R., Blairvacq, M., Meijer, L., Nakao, Y. & Karuso, P., 2011 4月 14, In: Journal of Medicinal Chemistry. 54, 7, p. 2492-2503 12 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51

Takaku, M., Kainuma, T., Ishida-Takaku, T., Ishigami, S., Suzuki, H., Tashiro, S., van Soest, R. W. M., Nakao, Y. & Kurumizaka, H., 2011 4月, In: Genes to Cells. 16, 4, p. 427-436 10 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata

Murayama, S., Imae, Y., Takada, K., Kikuchi, J., Nakao, Y., Van Soest, R. W. M., Okada, S. & Matsunaga, S., 2011 11月 15, In: Bioorganic and Medicinal Chemistry. 19, 22, p. 6594-6598 5 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

2009

A new antiangiogenic C₂₄ oxylipin from the soft coral Sinularia numerosa

Yamashita, T., Nakao, Y., Matsunaga, S., Oikawa, T., Imahara, Y. & Fusetani, N., 2009 3月 15, In: Bioorganic and Medicinal Chemistry. 17, 6, p. 2181-2184 4 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis

Ueoka, R., Nakao, Y., Kawatsu, S., Yaegashi, J., Matsumoto, Y., Matsunaga, S., Furihata, K., Van Soest, R. W. M. & Fusetani, N., 2009 6月 5, In: Journal of Organic Chemistry. 74, 11, p. 4203-4207 5 p.

研究成果: Article › 査読

59 被引用数 (Scopus)

Intramolecular ester exchange of potent cytotoxic kulokekahilide-2

Umehara, M., Takada, Y., Nakao, Y. & Kimura, J., 2009 2月 18, In: Tetrahedron Letters. 50, 7, p. 840-843 4 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

2008

Aplysinoplides A-C, cytotoxic sesterterpenes from the marine sponge Aplysinopsis digitata

Ueoka, R., Nakao, Y., Fujii, S., Van Soest, R. W. M. & Matsunaga, S., 2008 6月, In: Journal of Natural Products. 71, 6, p. 1089-1091 3 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex

Murayama, S., Nakao, Y. & Matsunaga, S., 2008 6月 23, In: Tetrahedron Letters. 49, 26, p. 4186-4188 3 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

中尾 洋一

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中尾洋一