α-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats

I. Ikeda, K. Wakamatsu, A. Inayoshi, K. Imaizumi, M. Sugano, Kazunaga Yazawa

研究成果: Article査読

98 被引用数 (Scopus)

抄録

Rats were fed purified diets containing 10% fat with constant (n-6):(n-3) polyunsaturated fatty acids [(n-6):(n-3); 2.3-2.6] and polyunsaturated:saturated fatty acids (1) ratios. This was obtained with α- linolenic acid, eicosapentaenoic acid and docosahexaenoic acid added at 1 g/100 g diet. Eicosapentaenoic acid and docosahexaenoic acid were added as the ethyl esters. The concentration of plasma cholesterol in rats fed docosahexaenoic acid was significantly lower than in those fed α-linolenic acid. The concentration of plasma triglyceride was significantly lower in rats fed eicosapentaenoic acid than in those fed docosahexaenoic acid. Docosahexaenoic acid significantly reduced hepatic cholesterol compared with α-linolenic acid and eicosapentaenoic acid. Both eicosapentaenoic acid and docosahexaenoic acid decreased hepatic triglyceride compared with α- linolenic acid, but this effect was more pronounced in the docosahexaenoic acid group. There was no significant difference in fecal excretion of neutral and acidic steroids and apparent fat absorption. In rats fed docosahexaenoic acid, the proportion of arachidonic acid in liver microsomal phosphatidylcholine was lower than in those fed eicosapentaenoic acid. The same tendency was observed in plasma, platelet and aortic phosphatidylcholine and liver microsomal phosphatidylethanolamine and phosphatidylinositol. Dietary docosahexaenoic acid, but not eicosapentaenoic acid, significantly decreased aortic production of prostacyclin compared to α-linolenic acid, whereas platelet aggregation by collagen was not affected by the difference in dietary (n-3) polyunsaturated fatty acids.

本文言語English
ページ(範囲)1898-1906
ページ数9
ジャーナルJournal of Nutrition
124
10
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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