β1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo

Yoshikuni Edagawa, Chie Yamaguchi, Hiroshi Saito, Tadahiro Takeda, Noriko Shimizu, Takao Narui, Shoji Shibata, Yoshihisa Ito

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The mechanism underlying the enhancement of long-term potentiation (LTP) induced by the systemic administration of PB-2, an α(1-3)(1-4)glucan- containing fraction extracted from the lichen Flavoparmelia baltimorensis and a putative LTP-enhancing agent, was investigated in the rat dentate gyrus in vivo. Particular attention was paid to the role of adrenaline β-receptors. An intravenous (i.v.) injection of PB-2 enhanced the induction of LTP, which was in turn inhibited by an i.v. injection of the adrenaline β1- receptor antagonist atenolol. An intracerebroventricular injection of atenolol did not affect the induction of LTP, but completely suppressed the PB-2-induced enhancement of LTP. The infusion of atenolol into the recording site attenuated the PB-2-induced facilitation of LTP. These results suggest that the adrenaline β1-receptors contribute to the enhancement of LTP induced by the systemic administration of PB-2, and that the functional β1- receptors are located both centrally and peripherally.

本文言語English
ページ(範囲)363-368
ページ数6
ジャーナルNeuroscience Research
53
4
DOI
出版ステータスPublished - 2005 12

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 「β<sub>1</sub>-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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