γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice

Salina Akter, Hiroyuki Sasaki, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata

研究成果: Article査読

抄録

We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFos levels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.

本文言語English
ページ(範囲)155-159
ページ数5
ジャーナルJournal of Pharmacological Sciences
138
2
DOI
出版ステータスPublished - 2018 10

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

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