γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice

Salina Akter; Hiroyuki Sasaki; Yuko Ikeda; Hiroki Miyakawa; Shigenobu Shibata

doi:10.1016/j.jphs.2018.06.003

γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice

Salina Akter, Hiroyuki Sasaki, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

抄録

We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFos levels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.

本文言語	English
ページ（範囲）	155-159
ページ数	5
ジャーナル	Journal of Pharmacological Sciences
巻	138
号	2
DOI	https://doi.org/10.1016/j.jphs.2018.06.003
出版ステータス	Published - 2018 10月

ASJC Scopus subject areas

分子医療
薬理学

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10.1016/j.jphs.2018.06.003

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title = "γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice",

abstract = "We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFos levels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.",

keywords = "Anxiety, Behavioral tests, cFos",

author = "Salina Akter and Hiroyuki Sasaki and Yuko Ikeda and Hiroki Miyakawa and Shigenobu Shibata",

note = "Funding Information: This work was partially supported by the Council for Science, Technology and Innovation ; and the cross-ministerial Strategic Innovation Promotion Program (SIP) with the grant number #2017-A074 . Publisher Copyright: {\textcopyright} 2018 The Authors",

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doi = "10.1016/j.jphs.2018.06.003",

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T1 - γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice

AU - Akter, Salina

AU - Sasaki, Hiroyuki

AU - Ikeda, Yuko

AU - Miyakawa, Hiroki

AU - Shibata, Shigenobu

N1 - Funding Information: This work was partially supported by the Council for Science, Technology and Innovation ; and the cross-ministerial Strategic Innovation Promotion Program (SIP) with the grant number #2017-A074 . Publisher Copyright: © 2018 The Authors

PY - 2018/10

Y1 - 2018/10

N2 - We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFos levels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.

AB - We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFos levels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.

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KW - Behavioral tests

KW - cFos

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γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice

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