17(ß-Hydroxy-16α-[125I]iodowortmannin, a sensitive labeling agent for pi 3-kinases

Shinobu Honzawa, Hiroshi Kurosu, Osamu Hazeki, Toshiaki Katada, Masakatsu Shibasaki, Masahisa Nakada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

To detect phosphatidylinositol (PI) 3-kinases with high sensitivity, we designed and prepared a radiolabeled derivative of wortmannin (1), a potent inhibitor of PI 3-kinases. The synthesized derivative, 17ß-hydroxy-16α-[125I]iodowortmannin (7), showed an IC50 that was 100-fold higher than that of wortmannin itself and which bound to catalytic subunits of PI 3-kinases.

本文言語English
ページ(範囲)2276-2278
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
43
12
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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