2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Lilia Lohrey, Takahiro N. Uehara, Satoshi Tani, Junichiro Yamaguchi, Hans Ulrich Humpf, Kenichiro Itami

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected.

本文言語English
ページ(範囲)3387-3394
ページ数8
ジャーナルEuropean Journal of Organic Chemistry
2014
16
DOI
出版ステータスPublished - 2014 6
外部発表はい

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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