抄録
Demethylnobiletins are nobiletin metabolites, with 4′-demethylnobiletin being the most abundant in the demethylated compounds upon feeding with nobiletin. Previous studies have repeatedly shown that demethylnobiletin has higher physiological activity than nobiletin; however, no studies have yet suggested that 4′-demethylnobiletin could affect biological rhythms. Therefore, in the present study, we analyzed the effects of fermented Citrus reticulata, containing a large amount of 4′-demethylnobiletin, on the locomotor activity level, locomotor activity rhythms under normal light-dark and constant-dark conditions, and peripheral clock rhythms. We demonstrated that fermented Citrus reticulata not only modified the changes in the locomotor activity rhythms caused by high-fat diet feeding in mice but also inhibited the phase shift of the peripheral clock rhythms caused by high-fat diet feeding. Taken together, the results of this study suggest that fermented Citrus reticulata could potentially be a new functional food that could help to maintain normal biological rhythms.
本文言語 | English |
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ページ(範囲) | 1509-1522 |
ページ数 | 14 |
ジャーナル | Biological Rhythm Research |
巻 | 53 |
号 | 10 |
DOI | |
出版ステータス | Published - 2022 |
ASJC Scopus subject areas
- 生態、進化、行動および分類学
- 生理学
- 生理学(医学)