5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex

Yoshikuni Edagawa, Hiroshi Saito, Kazuho Abe

研究成果: Article

49 引用 (Scopus)

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We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.

元の言語English
ページ(範囲)221-224
ページ数4
ジャーナルEuropean Journal of Pharmacology
349
発行部数2-3
DOI
出版物ステータスPublished - 1998 5 22
外部発表Yes

ASJC Scopus subject areas

  • Pharmacology

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