8-Oxo-7,8-dihydroguanine: Links to gene expression, aging, and defense against oxidative stress

Zsolt Radak*, Istvan Boldogh

*この研究の対応する著者

研究成果: Article査読

96 被引用数 (Scopus)

抄録

The one-electron oxidation product of guanine, 8-oxo-7,8-dihydroguanine (8-oxoG), is an abundant lesion in genomic, mitochondrial, and telomeric DNA and RNA. It is considered to be a marker of oxidative stress that preferentially accumulates at the 5' end of guanine strings in the DNA helix, in guanine quadruplexes, and in RNA molecules. 8-OxoG has a lower oxidation potential compared to guanine; thus it is susceptible to oxidation/reduction and, along with its redox products, is traditionally considered to be a major mutagenic DNA base lesion. It does not change the architecture of the DNA double helix and it is specifically recognized and excised by 8-oxoguanine DNA glycosylase (OGG1) during the DNA base excision repair pathway. OGG1 null animals accumulate excess levels of 8-oxoG in their genome, yet they do not have shorter life span nor do they exhibit severe pathological symptoms including tumor formation. In fact they are increasingly resistant to inflammation. Here we address the rarely considered significance of 8-oxoG, such as its optimal levels in DNA and RNA under a given condition, essentiality for normal cellular physiology, evolutionary role, and ability to soften the effects of oxidative stress in DNA, and the harmful consequences of its repair, as well as its importance in transcriptional initiation and chromatin relaxation.

本文言語English
ページ(範囲)587-596
ページ数10
ジャーナルFree Radical Biology and Medicine
49
4
DOI
出版ステータスPublished - 2010 8
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生理学(医学)

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