A 12-week after-school physical activity programme improves endothelial cell function in overweight and obese children: a randomised controlled study

Jong Hwan Park, Masashi Miyashita, Yoo Chan Kwon, Hyun Tae Park, Eun Hee Kim, Jin Kee Park, Ki Beam Park, Suk Ran Yoon, Jin Woong Chung, Yoshio Nakamura, Sang Kab Park*

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Background: Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.Methods: A total of 29 overweight/obese children (12.2 ± 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34+ (a cell surface marker on hematopoietic stem cells), CD133+ (a cell surface marker on hematopoietic progenitor cells) and CD34+/CD133+ (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.Results: Increased percentages of CD34+, CD133+ and CD34+/CD133+ cells were observed in the after-school exercise group (p = 0.018; p = 0.001; p = 0.002, respectively) compared with the control group. Carotid intima-media thickness decreased after 12 weeks in the after-school exercise group (p = 0.020) compared with the control group.Conclusions: This study provides preliminary evidence that a combined after-school exercise programme may represent an effective intervention strategy for improving vascular repair and endothelial cell function, leading to improved cardiovascular health in overweight and obese children.Trial registration: Current Controlled Trials ISRCTN19037201.

本文言語English
論文番号111
ジャーナルBMC Pediatrics
12
DOI
出版ステータスPublished - 2012 7 31

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康

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