A compact chemical miniature of a holoenzyme, coenzyme NADH linked dehydrogenase. Design and synthesis of bridged NADH models and their highly enantioselective reduction

Medicine & Life Sciences

• NADH Dehydrogenase 75%
• Holoenzymes 69%
• Coenzymes 68%
• NAD 54%
• Biomimetics 19%
• Phosphoranes 18%
• Hydrogen 17%
• Pyruvic Acid 16%
• Lactic Acid 13%
• pyridine 9%
• Ketones 9%
• Niacin 9%
• Isotopes 8%
• Glycolysis 7%
• Magnesium 7%
• L-Lactate Dehydrogenase 7%
• Ions 6%
• Alcohols 5%
• Temperature 5%
• Enzymes 4%

Engineering & Materials Science

• Coenzymes 100%
• Oxidoreductases 80%
• Enantioselectivity 39%
• Chirality 20%
• Biomimetics 15%
• Glycolysis 11%
• Pyridine 10%
• Hydrogen 10%
• Ketones 9%
• Isotopes 8%
• Enzymes 7%
• Alcohols 7%
• Magnesium 6%
• Shielding 6%
• Ions 6%
• Temperature 2%
• Experiments 2%

Chemical Compounds

• Coenzyme 56%
• Carbamoyl Group 27%
• Reduction 24%
• Enantioselectivity 23%
• Pyruvate 18%
• Chirality 16%
• Nicotinate 12%
• Phosphorane 12%
• Magnesium Ion 10%
• Lactate 8%
• Hydrogen 8%
• Isotope 7%
• Alcohol 5%